Exploitation of Drosophila Choriogenesis Process as a Model Cellular System for Assessment of Compound Toxicity: the Phloroglucinol Paradigm

Phloroglucinol (1,3,5 tri-hydroxy-benzene) (PGL), a natural phenolic substance, is a peroxidase inhibitor and has anti-oxidant, anti-diabetic, anti-inflammatory, anti-thrombotic, radio-protective, spasmolytic and anti-cancer activities. PGL, as a medicine, is administered to patients to control the...

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Veröffentlicht in:	Scientific reports 2020-01, Vol.10 (1), p.242, Article 242
Hauptverfasser:	Keramaris, Konstantinos E., Konstantopoulos, Konstantinos, Margaritis, Lukas H., Velentzas, Athanassios D., Papassideri, Issidora S., Stravopodis, Dimitrios J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 14/28 45/29 631/80 631/92 64 64/24 82 96/63 Animals Apoptosis Benzene Cell death Cell differentiation Chorion Chorion - drug effects Chorion - growth & development Chromatin Clinical trials Cytoplasm Cytotoxicity Diabetes mellitus Dose-Response Relationship, Drug Drosophila Drosophila melanogaster - drug effects Drosophila melanogaster - embryology Endoplasmic reticulum Epithelial cells Female Follicles Humanities and Social Sciences Inflammation Insects Intestine Irritable bowel syndrome multidisciplinary Nucleoli Oogenesis Ovarian Follicle - drug effects Ovarian Follicle - growth & development Oxidants Oxidizing agents Peroxidase Phagocytosis Phenols Phloroglucinol - toxicity Plasma membranes Protein biosynthesis Protein synthesis Science Science (multidisciplinary) Toxicity Toxicity Tests Vacuoles
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