High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma
Primary adenosquamous carcinoma (ASC) is a rare malignant tumor in the lung and its biological behavior has not yet been thoroughly described. In this study, we aimed to explore the clinical and biological role of CXCR4 in patients with resected lung ASC. We retrospectively reviewed the clinical rec...
Gespeichert in:
| Veröffentlicht in: | Journal of Cancer 2020, Vol.11 (4), p.810-818 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 818 |
|---|---|
| container_issue | 4 |
| container_start_page | 810 |
| container_title | Journal of Cancer |
| container_volume | 11 |
| creator | Zhu, Qiaoliang Luo, Rongkui Gu, Jie Hou, Yingyong Chen, Zongwei Xu, Fengkai Wang, Lin Mao, Wei Lu, Chunlai Ge, Di |
| description | Primary adenosquamous carcinoma (ASC) is a rare malignant tumor in the lung and its biological behavior has not yet been thoroughly described. In this study, we aimed to explore the clinical and biological role of CXCR4 in patients with resected lung ASC.
We retrospectively reviewed the clinical records of patients with histologically confirmed lung ASC who underwent surgical resection with systematic lymph node dissection. Immunohistochemical staining was performed to detect the expression of CXCR4 in tumor tissues. The correlation between CXCR4 expression and clinicopathological characteristics were evaluated. The association between CXCR4 expression and patients' prognosis was analyzed by Kaplan-Meier and Cox regression. Moreover, we performed
studies including CCK8, transwell and cell apoptosis to explore the potential role of CXCR4 in lung ASC.
A total of 78 patients with resected lung ASC were reviewed. Seventy (89.7%) patient tumors expressed CXCR4, with high level of CXCR4 expression observed in 45 (57.7%) cases.
, CXCR4 conferred no difference in proliferative capacity but increased invasive potential, enhanced chemoresistance and inhibited apoptosis of lung ASC. Clinically, high CXCR4 expression was significantly associated with solid ASC, lymph node metastasis and advanced TNM stage. Patients with high CXCR4 expression and solid ASC had decreased disease-free survival and overall survival.
CXCR4 was commonly expressed in lung ASC tumors. High CXCR4 expression might be a novel marker in predicting a poor prognosis in resected lung ASC and might serve as a potential therapeutic target. |
| doi_str_mv | 10.7150/jca.36498 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6959020</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2341614743</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-7a905ad58c2a0e166c6dc8dcf0d5550d8d457605fa958d7282575fb7bcd2e6323</originalsourceid><addsrcrecordid>eNpdkctKLDEQhoMoKurCF5DA2RwXo7l3sjkgjTcYUETBXcgk6THDdDIm3aJvb7zisTZVRX38VNUPwD5GRw3m6HhhzREVTMk1sI0lbSZKCLb-o94Ce6UsUA2qSMPoJtiiWDHFJNsG9xdh_gDb-_aGwdPnVfalhBThdfYu2KFAA69TyrVP85hKKDBEeOOLt4N3cDrGOTxxvk4eR9OnscDWZBti6s0u2OjMsvi9z7wD7s5Ob9uLyfTq_LI9mU4sQ3SYNEYhbhyXlhjksRBWOCud7ZDjnCMnHeONQLwzikvXEEl4w7tZM7OOeEEJ3QH_PnRX46z3zvo4ZLPUqxx6k190MkH_P4nhQc_TkxaKK0RQFfj7KZDT4-jLoPtQrF8uTfT1Ik0owwKz-riK_vmFLtKYYz1PE64k5YpgVanDD8rmVEr23fcyGOk3y3S1TL9bVtmDn9t_k18G0VdaZZFU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2598359219</pqid></control><display><type>article</type><title>High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma</title><source>PubMed Central</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Zhu, Qiaoliang ; Luo, Rongkui ; Gu, Jie ; Hou, Yingyong ; Chen, Zongwei ; Xu, Fengkai ; Wang, Lin ; Mao, Wei ; Lu, Chunlai ; Ge, Di</creator><creatorcontrib>Zhu, Qiaoliang ; Luo, Rongkui ; Gu, Jie ; Hou, Yingyong ; Chen, Zongwei ; Xu, Fengkai ; Wang, Lin ; Mao, Wei ; Lu, Chunlai ; Ge, Di</creatorcontrib><description>Primary adenosquamous carcinoma (ASC) is a rare malignant tumor in the lung and its biological behavior has not yet been thoroughly described. In this study, we aimed to explore the clinical and biological role of CXCR4 in patients with resected lung ASC.
We retrospectively reviewed the clinical records of patients with histologically confirmed lung ASC who underwent surgical resection with systematic lymph node dissection. Immunohistochemical staining was performed to detect the expression of CXCR4 in tumor tissues. The correlation between CXCR4 expression and clinicopathological characteristics were evaluated. The association between CXCR4 expression and patients' prognosis was analyzed by Kaplan-Meier and Cox regression. Moreover, we performed
studies including CCK8, transwell and cell apoptosis to explore the potential role of CXCR4 in lung ASC.
A total of 78 patients with resected lung ASC were reviewed. Seventy (89.7%) patient tumors expressed CXCR4, with high level of CXCR4 expression observed in 45 (57.7%) cases.
, CXCR4 conferred no difference in proliferative capacity but increased invasive potential, enhanced chemoresistance and inhibited apoptosis of lung ASC. Clinically, high CXCR4 expression was significantly associated with solid ASC, lymph node metastasis and advanced TNM stage. Patients with high CXCR4 expression and solid ASC had decreased disease-free survival and overall survival.
CXCR4 was commonly expressed in lung ASC tumors. High CXCR4 expression might be a novel marker in predicting a poor prognosis in resected lung ASC and might serve as a potential therapeutic target.</description><identifier>ISSN: 1837-9664</identifier><identifier>EISSN: 1837-9664</identifier><identifier>DOI: 10.7150/jca.36498</identifier><identifier>PMID: 31949484</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher Pty Ltd</publisher><subject>Apoptosis ; Lung cancer ; Lymphatic system ; Medical prognosis ; Metastasis ; Multivariate analysis ; Mutation ; Research Paper ; Software ; Statistical analysis ; Surgery ; Tumors</subject><ispartof>Journal of Cancer, 2020, Vol.11 (4), p.810-818</ispartof><rights>The author(s).</rights><rights>2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-7a905ad58c2a0e166c6dc8dcf0d5550d8d457605fa958d7282575fb7bcd2e6323</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959020/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959020/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,4010,27904,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31949484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Qiaoliang</creatorcontrib><creatorcontrib>Luo, Rongkui</creatorcontrib><creatorcontrib>Gu, Jie</creatorcontrib><creatorcontrib>Hou, Yingyong</creatorcontrib><creatorcontrib>Chen, Zongwei</creatorcontrib><creatorcontrib>Xu, Fengkai</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Mao, Wei</creatorcontrib><creatorcontrib>Lu, Chunlai</creatorcontrib><creatorcontrib>Ge, Di</creatorcontrib><title>High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma</title><title>Journal of Cancer</title><addtitle>J Cancer</addtitle><description>Primary adenosquamous carcinoma (ASC) is a rare malignant tumor in the lung and its biological behavior has not yet been thoroughly described. In this study, we aimed to explore the clinical and biological role of CXCR4 in patients with resected lung ASC.
We retrospectively reviewed the clinical records of patients with histologically confirmed lung ASC who underwent surgical resection with systematic lymph node dissection. Immunohistochemical staining was performed to detect the expression of CXCR4 in tumor tissues. The correlation between CXCR4 expression and clinicopathological characteristics were evaluated. The association between CXCR4 expression and patients' prognosis was analyzed by Kaplan-Meier and Cox regression. Moreover, we performed
studies including CCK8, transwell and cell apoptosis to explore the potential role of CXCR4 in lung ASC.
A total of 78 patients with resected lung ASC were reviewed. Seventy (89.7%) patient tumors expressed CXCR4, with high level of CXCR4 expression observed in 45 (57.7%) cases.
, CXCR4 conferred no difference in proliferative capacity but increased invasive potential, enhanced chemoresistance and inhibited apoptosis of lung ASC. Clinically, high CXCR4 expression was significantly associated with solid ASC, lymph node metastasis and advanced TNM stage. Patients with high CXCR4 expression and solid ASC had decreased disease-free survival and overall survival.
CXCR4 was commonly expressed in lung ASC tumors. High CXCR4 expression might be a novel marker in predicting a poor prognosis in resected lung ASC and might serve as a potential therapeutic target.</description><subject>Apoptosis</subject><subject>Lung cancer</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>Mutation</subject><subject>Research Paper</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Tumors</subject><issn>1837-9664</issn><issn>1837-9664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkctKLDEQhoMoKurCF5DA2RwXo7l3sjkgjTcYUETBXcgk6THDdDIm3aJvb7zisTZVRX38VNUPwD5GRw3m6HhhzREVTMk1sI0lbSZKCLb-o94Ce6UsUA2qSMPoJtiiWDHFJNsG9xdh_gDb-_aGwdPnVfalhBThdfYu2KFAA69TyrVP85hKKDBEeOOLt4N3cDrGOTxxvk4eR9OnscDWZBti6s0u2OjMsvi9z7wD7s5Ob9uLyfTq_LI9mU4sQ3SYNEYhbhyXlhjksRBWOCud7ZDjnCMnHeONQLwzikvXEEl4w7tZM7OOeEEJ3QH_PnRX46z3zvo4ZLPUqxx6k190MkH_P4nhQc_TkxaKK0RQFfj7KZDT4-jLoPtQrF8uTfT1Ik0owwKz-riK_vmFLtKYYz1PE64k5YpgVanDD8rmVEr23fcyGOk3y3S1TL9bVtmDn9t_k18G0VdaZZFU</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Zhu, Qiaoliang</creator><creator>Luo, Rongkui</creator><creator>Gu, Jie</creator><creator>Hou, Yingyong</creator><creator>Chen, Zongwei</creator><creator>Xu, Fengkai</creator><creator>Wang, Lin</creator><creator>Mao, Wei</creator><creator>Lu, Chunlai</creator><creator>Ge, Di</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2020</creationdate><title>High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma</title><author>Zhu, Qiaoliang ; Luo, Rongkui ; Gu, Jie ; Hou, Yingyong ; Chen, Zongwei ; Xu, Fengkai ; Wang, Lin ; Mao, Wei ; Lu, Chunlai ; Ge, Di</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-7a905ad58c2a0e166c6dc8dcf0d5550d8d457605fa958d7282575fb7bcd2e6323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>Lung cancer</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Multivariate analysis</topic><topic>Mutation</topic><topic>Research Paper</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Qiaoliang</creatorcontrib><creatorcontrib>Luo, Rongkui</creatorcontrib><creatorcontrib>Gu, Jie</creatorcontrib><creatorcontrib>Hou, Yingyong</creatorcontrib><creatorcontrib>Chen, Zongwei</creatorcontrib><creatorcontrib>Xu, Fengkai</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Mao, Wei</creatorcontrib><creatorcontrib>Lu, Chunlai</creatorcontrib><creatorcontrib>Ge, Di</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Qiaoliang</au><au>Luo, Rongkui</au><au>Gu, Jie</au><au>Hou, Yingyong</au><au>Chen, Zongwei</au><au>Xu, Fengkai</au><au>Wang, Lin</au><au>Mao, Wei</au><au>Lu, Chunlai</au><au>Ge, Di</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma</atitle><jtitle>Journal of Cancer</jtitle><addtitle>J Cancer</addtitle><date>2020</date><risdate>2020</risdate><volume>11</volume><issue>4</issue><spage>810</spage><epage>818</epage><pages>810-818</pages><issn>1837-9664</issn><eissn>1837-9664</eissn><abstract>Primary adenosquamous carcinoma (ASC) is a rare malignant tumor in the lung and its biological behavior has not yet been thoroughly described. In this study, we aimed to explore the clinical and biological role of CXCR4 in patients with resected lung ASC.
We retrospectively reviewed the clinical records of patients with histologically confirmed lung ASC who underwent surgical resection with systematic lymph node dissection. Immunohistochemical staining was performed to detect the expression of CXCR4 in tumor tissues. The correlation between CXCR4 expression and clinicopathological characteristics were evaluated. The association between CXCR4 expression and patients' prognosis was analyzed by Kaplan-Meier and Cox regression. Moreover, we performed
studies including CCK8, transwell and cell apoptosis to explore the potential role of CXCR4 in lung ASC.
A total of 78 patients with resected lung ASC were reviewed. Seventy (89.7%) patient tumors expressed CXCR4, with high level of CXCR4 expression observed in 45 (57.7%) cases.
, CXCR4 conferred no difference in proliferative capacity but increased invasive potential, enhanced chemoresistance and inhibited apoptosis of lung ASC. Clinically, high CXCR4 expression was significantly associated with solid ASC, lymph node metastasis and advanced TNM stage. Patients with high CXCR4 expression and solid ASC had decreased disease-free survival and overall survival.
CXCR4 was commonly expressed in lung ASC tumors. High CXCR4 expression might be a novel marker in predicting a poor prognosis in resected lung ASC and might serve as a potential therapeutic target.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher Pty Ltd</pub><pmid>31949484</pmid><doi>10.7150/jca.36498</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1837-9664 |
| ispartof | Journal of Cancer, 2020, Vol.11 (4), p.810-818 |
| issn | 1837-9664 1837-9664 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6959020 |
| source | PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Apoptosis Lung cancer Lymphatic system Medical prognosis Metastasis Multivariate analysis Mutation Research Paper Software Statistical analysis Surgery Tumors |
| title | High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T15%3A50%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20CXCR4%20Expression%20Predicts%20a%20Poor%20Prognosis%20in%20Resected%20Lung%20Adenosquamous%20Carcinoma&rft.jtitle=Journal%20of%20Cancer&rft.au=Zhu,%20Qiaoliang&rft.date=2020&rft.volume=11&rft.issue=4&rft.spage=810&rft.epage=818&rft.pages=810-818&rft.issn=1837-9664&rft.eissn=1837-9664&rft_id=info:doi/10.7150/jca.36498&rft_dat=%3Cproquest_pubme%3E2341614743%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2598359219&rft_id=info:pmid/31949484&rfr_iscdi=true |