The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa

Gastric carcinoma is related mostly to CagA+-Helicobacter pylori infection, which disrupts the gastric mucosa turnover and elicits an epithelial-mesenchymal transition (EMT) and preneoplastic transdifferentiation. The tumor suppressor Hippo pathway controls stem cell homeostasis; its core, constitut...

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Veröffentlicht in:	Cellular and molecular gastroenterology and hepatology 2020-01, Vol.9 (2), p.257-276
Hauptverfasser:	Molina-Castro, Silvia Elena, Tiffon, Camille, Giraud, Julie, Boeuf, Hélène, Sifre, Elodie, Giese, Alban, Belleannée, Geneviève, Lehours, Philippe, Bessède, Emilie, Mégraud, Francis, Dubus, Pierre, Staedel, Cathy, Varon, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - immunology Adenocarcinoma - pathology Aged Aged, 80 and over Animals CagA Cell Cycle Proteins - metabolism Epithelial-Mesenchymal Transition - immunology Epithelial-to-Mesenchymal Transition Female Gastric Mucosa - microbiology Gastric Mucosa - pathology Gene Expression Regulation, Neoplastic - immunology Helicobacter Infections - genetics Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori - pathogenicity Host-Pathogen Interactions - genetics Humans Life Sciences Male Metaplasia - genetics Metaplasia - microbiology Metaplasia - pathology Mice Original Research Precancerous Conditions - genetics Precancerous Conditions - immunology Precancerous Conditions - pathology Protective Factors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Signal Transduction - genetics Signal Transduction - immunology Stomach Neoplasms - genetics Stomach Neoplasms - immunology Stomach Neoplasms - pathology Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism YAP1
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