GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cells

Recent studies have shown that 20-hydroxyeicosatetraenoic acid (20-HETE) is a key molecule in sustaining androgen-mediated prostate cancer cell survival. Thus, the aim of this study was to determine whether 20-HETE can affect the metastatic potential of androgen-insensitive prostate cancer cells, an...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids 2020-02, Vol.1865 (2), p.158573-158573, Article 158573
Hauptverfasser:	Cárdenas, Sofia, Colombero, Cecilia, Panelo, Laura, Dakarapu, Rambabu, Falck, John R., Costas, Monica A., Nowicki, Susana
Format:	Artikel
Sprache:	eng
Schlagworte:	20-HETE actin agar agonists Amidines - pharmacology Androgens - metabolism antagonists Arachidonic acid metabolites cell movement Cell Movement - drug effects cell viability Epithelial-Mesenchymal Transition - drug effects fluorescence microscopy Gene Knockdown Techniques gene silencing GPR75 receptor Humans Hydroxyeicosatetraenoic Acids - agonists Hydroxyeicosatetraenoic Acids - antagonists & inhibitors Hydroxyeicosatetraenoic Acids - metabolism in vitro studies Intracellular Signaling Peptides and Proteins - metabolism LIM Domain Proteins - metabolism Male Matrix Metalloproteinase 2 - metabolism Metastasis neoplasm cells PC-3 Cells phenotype polymerization Prostate cancer prostatic neoplasms Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology protein kinase C protein phosphorylation Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism RNA, Small Interfering - metabolism Signal Transduction - drug effects tissue repair transcription factor NF-kappa B Western blotting
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