Conserved mechanism of phospholipid substrate recognition by the P4-ATPase Neo1 from Saccharomyces cerevisiae

The type IV P-type ATPases (P4-ATPases) thus far characterized are lipid flippases that transport specific substrates, such as phosphatidylserine (PS) and phosphatidylethanolamine (PE), from the exofacial leaflet to the cytofacial leaflet of membranes. This transport activity generates compositional...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids 2020-02, Vol.1865 (2), p.158581-158581, Article 158581
Hauptverfasser:	Huang, Yannan, Takar, Mehmet, Best, Jordan T., Graham, Todd R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism ATP9A Calcium-Transporting ATPases - genetics Calcium-Transporting ATPases - metabolism Cell Membrane - metabolism Gain of Function Mutation Membrane asymmetry Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mutagenesis Neo1 P4-ATPase Phosphatidylethanolamine Phosphatidylethanolamines - metabolism Phosphatidylserine Phosphatidylserines - metabolism Phospholipid Transfer Proteins - genetics Phospholipid Transfer Proteins - metabolism Point Mutation Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Substrate Specificity - genetics
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