Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling

The pathophysiology of pulmonary hypertension (PH) and heart failure (HF) includes fibrogenic remodeling associated with the loss of pulmonary arterial (PA) and cardiac compliance. We and others have previously identified transglutaminase 2 (TG2) as a participant in adverse fibrogenic remodeling. Ho...

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Veröffentlicht in:	The FASEB journal 2020-01, Vol.34 (1), p.930-944
Hauptverfasser:	Bhedi, Chinmayee D., Nasirova, Sabina, Toksoz, Deniz, Warburton, Rod R., Morine, Kevin J., Kapur, Navin K., Galper, Jonas B., Preston, Ioana R., Hill, Nicholas S., Fanburg, Barry L., Penumatsa, Krishna C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - metabolism Cell Proliferation Fibroblasts - metabolism Gene Expression Regulation, Enzymologic Glucose - metabolism Glycolysis GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Humans hyperglycemia Hyperglycemia - metabolism Hypertension, Pulmonary - metabolism Membrane Proteins - metabolism Mice Mice, Inbred C57BL PKM2 Protein Glutamine gamma Glutamyltransferase 2 Pulmonary Artery - metabolism Pyruvate Kinase - metabolism Signal Transduction TG2 Thyroid Hormone-Binding Proteins Thyroid Hormones - metabolism tissue fibrosis Transglutaminases - genetics Transglutaminases - metabolism Up-Regulation
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