Asthma Case Cluster during Renovation of a Water-Damaged and Toxic Building
An association between fungal exposure at work and asthma onset has been shown, but a causal relationship between them has not beTanle en established. The study describes an asthma cluster in workers in a building under renovation. Before renovation the work site had significant water damage, techni...
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| Veröffentlicht in: | Microorganisms (Basel) 2019-12, Vol.7 (12), p.642 |
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| creator | Hyvönen, Saija Syrjala, Hannu |
| description | An association between fungal exposure at work and asthma onset has been shown, but a causal relationship between them has not beTanle en established.
The study describes an asthma cluster in workers in a building under renovation. Before renovation the work site had significant water damage, technical deficiencies, and ventilation problems. Worker protection was insufficient during renovation. In the building, toxicity was determined from dust as well as from cultured dust. Toxicity analysis was conducted in vitro using the boar spermatozoa motility assay.
During the 8-month renovation period, among 290 workers, 21 (7.2%) experienced new-onset asthma (9 women, 42.9%; 12 men, 57.1%; median age, 43 years (range, 30-60 years)). At the renovation site, they had been exposed to areas where remarkable toxicity was demonstrated in vitro. One year later, 13 (61.9%) of them still had moderate disease, and three (14.8%) had severe disease. Most patients had a poor response to inhaled corticosteroids.
This study documents a clear temporal association between occupational exposure during renovation of a water-damaged building and a cluster of 21 new occupational asthma cases. In addition, dust and cultured dust from their work spaces showed remarkable toxicity based on inhibition of boar sperm motility in vitro. |
| doi_str_mv | 10.3390/microorganisms7120642 |
| format | Article |
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The study describes an asthma cluster in workers in a building under renovation. Before renovation the work site had significant water damage, technical deficiencies, and ventilation problems. Worker protection was insufficient during renovation. In the building, toxicity was determined from dust as well as from cultured dust. Toxicity analysis was conducted in vitro using the boar spermatozoa motility assay.
During the 8-month renovation period, among 290 workers, 21 (7.2%) experienced new-onset asthma (9 women, 42.9%; 12 men, 57.1%; median age, 43 years (range, 30-60 years)). At the renovation site, they had been exposed to areas where remarkable toxicity was demonstrated in vitro. One year later, 13 (61.9%) of them still had moderate disease, and three (14.8%) had severe disease. Most patients had a poor response to inhaled corticosteroids.
This study documents a clear temporal association between occupational exposure during renovation of a water-damaged building and a cluster of 21 new occupational asthma cases. In addition, dust and cultured dust from their work spaces showed remarkable toxicity based on inhibition of boar sperm motility in vitro.</description><identifier>ISSN: 2076-2607</identifier><identifier>EISSN: 2076-2607</identifier><identifier>DOI: 10.3390/microorganisms7120642</identifier><identifier>PMID: 31816917</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Asthma ; Clusters ; Concrete ; Corticoids ; Corticosteroids ; Cytokines ; Dust ; Ethanol ; Exposure ; Flooring ; Indoor air quality ; Mold ; Motility ; Occupational diseases ; Occupational exposure ; Occupational health ; Renovation & restoration ; Respiratory diseases ; Sperm ; Spermatozoa ; Toxicity ; Water damage</subject><ispartof>Microorganisms (Basel), 2019-12, Vol.7 (12), p.642</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-d626d5e76b8f0b25d1494dee44edf211004a23d3533757541e297f79f2c51fbd3</citedby><cites>FETCH-LOGICAL-c439t-d626d5e76b8f0b25d1494dee44edf211004a23d3533757541e297f79f2c51fbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956061/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956061/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31816917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hyvönen, Saija</creatorcontrib><creatorcontrib>Syrjala, Hannu</creatorcontrib><title>Asthma Case Cluster during Renovation of a Water-Damaged and Toxic Building</title><title>Microorganisms (Basel)</title><addtitle>Microorganisms</addtitle><description>An association between fungal exposure at work and asthma onset has been shown, but a causal relationship between them has not beTanle en established.
The study describes an asthma cluster in workers in a building under renovation. Before renovation the work site had significant water damage, technical deficiencies, and ventilation problems. Worker protection was insufficient during renovation. In the building, toxicity was determined from dust as well as from cultured dust. Toxicity analysis was conducted in vitro using the boar spermatozoa motility assay.
During the 8-month renovation period, among 290 workers, 21 (7.2%) experienced new-onset asthma (9 women, 42.9%; 12 men, 57.1%; median age, 43 years (range, 30-60 years)). At the renovation site, they had been exposed to areas where remarkable toxicity was demonstrated in vitro. One year later, 13 (61.9%) of them still had moderate disease, and three (14.8%) had severe disease. Most patients had a poor response to inhaled corticosteroids.
This study documents a clear temporal association between occupational exposure during renovation of a water-damaged building and a cluster of 21 new occupational asthma cases. In addition, dust and cultured dust from their work spaces showed remarkable toxicity based on inhibition of boar sperm motility in vitro.</description><subject>Asthma</subject><subject>Clusters</subject><subject>Concrete</subject><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>Cytokines</subject><subject>Dust</subject><subject>Ethanol</subject><subject>Exposure</subject><subject>Flooring</subject><subject>Indoor air quality</subject><subject>Mold</subject><subject>Motility</subject><subject>Occupational diseases</subject><subject>Occupational exposure</subject><subject>Occupational health</subject><subject>Renovation & restoration</subject><subject>Respiratory diseases</subject><subject>Sperm</subject><subject>Spermatozoa</subject><subject>Toxicity</subject><subject>Water damage</subject><issn>2076-2607</issn><issn>2076-2607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUctKBDEQDKKo6H6CEvDiZTTvbC7Cuj5REETxGLKTzBqZSdZkRvTvjaiLin3phq6qfhQAOxgdUKrQYefrFGOam-BzlyUmSDCyAjYJkqIiAsnVH_UGGOX8hEooTMccr4MNisdYKCw3wdUk94-dgVOTHZy2Q-5dgnZIPszhrQvxxfQ-BhgbaOCDKc3qxHRm7iw0wcK7-OpreDz41hbCNlhrTJvd6Ctvgfuz07vpRXV9c345nVxXNaOqr6wgwnInxWzcoBnhFjPFrHOMOdsQjBFihlBLOaWSS86wI0o2UjWk5riZWboFjj51F8Osc7Z2oU-m1YvkO5PedDRe_-4E_6jn8UULxQUSuAjsfwmk-Dy43OvO59q1rQkuDlkTSigTZTQt0L0_0Kc4pFDO04QzhVB5pSoo_okqtuScXLNcBiP94Zj-17HC2_15yZL17Q99B65XlYo</recordid><startdate>20191203</startdate><enddate>20191203</enddate><creator>Hyvönen, Saija</creator><creator>Syrjala, Hannu</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191203</creationdate><title>Asthma Case Cluster during Renovation of a Water-Damaged and Toxic Building</title><author>Hyvönen, Saija ; Syrjala, Hannu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-d626d5e76b8f0b25d1494dee44edf211004a23d3533757541e297f79f2c51fbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Asthma</topic><topic>Clusters</topic><topic>Concrete</topic><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Cytokines</topic><topic>Dust</topic><topic>Ethanol</topic><topic>Exposure</topic><topic>Flooring</topic><topic>Indoor air quality</topic><topic>Mold</topic><topic>Motility</topic><topic>Occupational diseases</topic><topic>Occupational exposure</topic><topic>Occupational health</topic><topic>Renovation & restoration</topic><topic>Respiratory diseases</topic><topic>Sperm</topic><topic>Spermatozoa</topic><topic>Toxicity</topic><topic>Water damage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hyvönen, Saija</creatorcontrib><creatorcontrib>Syrjala, Hannu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Microorganisms (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hyvönen, Saija</au><au>Syrjala, Hannu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asthma Case Cluster during Renovation of a Water-Damaged and Toxic Building</atitle><jtitle>Microorganisms (Basel)</jtitle><addtitle>Microorganisms</addtitle><date>2019-12-03</date><risdate>2019</risdate><volume>7</volume><issue>12</issue><spage>642</spage><pages>642-</pages><issn>2076-2607</issn><eissn>2076-2607</eissn><abstract>An association between fungal exposure at work and asthma onset has been shown, but a causal relationship between them has not beTanle en established.
The study describes an asthma cluster in workers in a building under renovation. Before renovation the work site had significant water damage, technical deficiencies, and ventilation problems. Worker protection was insufficient during renovation. In the building, toxicity was determined from dust as well as from cultured dust. Toxicity analysis was conducted in vitro using the boar spermatozoa motility assay.
During the 8-month renovation period, among 290 workers, 21 (7.2%) experienced new-onset asthma (9 women, 42.9%; 12 men, 57.1%; median age, 43 years (range, 30-60 years)). At the renovation site, they had been exposed to areas where remarkable toxicity was demonstrated in vitro. One year later, 13 (61.9%) of them still had moderate disease, and three (14.8%) had severe disease. Most patients had a poor response to inhaled corticosteroids.
This study documents a clear temporal association between occupational exposure during renovation of a water-damaged building and a cluster of 21 new occupational asthma cases. In addition, dust and cultured dust from their work spaces showed remarkable toxicity based on inhibition of boar sperm motility in vitro.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31816917</pmid><doi>10.3390/microorganisms7120642</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Asthma Clusters Concrete Corticoids Corticosteroids Cytokines Dust Ethanol Exposure Flooring Indoor air quality Mold Motility Occupational diseases Occupational exposure Occupational health Renovation & restoration Respiratory diseases Sperm Spermatozoa Toxicity Water damage |
| title | Asthma Case Cluster during Renovation of a Water-Damaged and Toxic Building |
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