TCD Cerebral Hemodynamic Changes during Moderate‐Intensity Exercise in Older Adults
ABSTRACT BACKGROUND AND PURPOSE Exercise plays an important role in supporting overall brain health. However, the mechanisms by which exercise supports brain health are imprecisely defined. Further, brain hemodynamic changes during exercise are not clearly understood, especially in older adults. The...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroimaging 2020-01, Vol.30 (1), p.76-81 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 81 |
|---|---|
| container_issue | 1 |
| container_start_page | 76 |
| container_title | Journal of neuroimaging |
| container_volume | 30 |
| creator | Alwatban, Mohammed R. Liu, Yumei Perdomo, Sophy J. Ward, Jaimie L. Vidoni, Eric D. Burns, Jeffrey M. Billinger, Sandra A. |
| description | ABSTRACT
BACKGROUND AND PURPOSE
Exercise plays an important role in supporting overall brain health. However, the mechanisms by which exercise supports brain health are imprecisely defined. Further, brain hemodynamic changes during exercise are not clearly understood, especially in older adults. The primary aim of this study was to compare cerebral blood flow velocity and pulsatility index (PI) during moderate‐intensity exercise between older adults with normal pulsatile flow (normal PI) and older adults with elevated pulsatile flow (elevated PI). Secondary aims were to compare cardiovascular disease risk and cognitive function between individuals with elevated and nonelevated PI.
METHODS
Using transcranial Doppler ultrasound (TCD), middle cerebral artery blood velocity (MCAv) and PI were recorded during the rest and moderate‐intensity exercise. End tidal carbon dioxide (PETCO2) and beat‐to‐beat mean arterial blood pressure were also recorded.
RESULTS
We enrolled 104 older adults into the study. The change in PI was greater in normal PI group (35.5% vs. 21.3%, P = .005). The change in MCAv was similar in both groups (11.6% for normal PI vs. 10.6% for elevated PI; P = .22). There was no significant difference in cardiovascular disease risk between the two groups (P = .77). Individuals with elevated PI performed significantly worse in WAIS‐R Digit Symbol and Trail Making Test A (P = .04 and = .01, respectively).
CONCLUSIONS
The percent increase in PI from rest to moderate‐intensity exercise was attenuated in the older adults with elevated resting PI. Higher resting PI may negatively affect brain health as evidenced by the slower processing speed scores. |
| doi_str_mv | 10.1111/jon.12675 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6954976</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2335470078</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4435-80c0b81a02482c37de462871f41c575843e4376538f436b672214169f3c206623</originalsourceid><addsrcrecordid>eNp1kc1OFTEYhidGI4guvAHTxI0sBvrfzsaEDCgY9Gxg3fR0vjn0ZKbFdkY4Oy_Ba-RKqB4kamI3bfI9ffK9eavqNcEHpJzDdQwHhEolnlS7RAhaSyGbp-WNBakp1XynepHzGmNKOGXPqx1GlMCiYbvV5UV7jFpIsEx2QKcwxm4T7Ogdaq9sWEFG3Zx8WKHPsYNkJ7j7_uMsTBCynzbo5BaS8xmQD2gxFAAddfMw5ZfVs94OGV493HvV5YeTi_a0Pl98PGuPzmvHORO1xg4vNbGYck0dUx1wSbUiPSdOKKE5A86UFEz3nMmlVLQEILLpmaNYSsr2qvdb7_W8HKFzEKYSw1wnP9q0MdF68_ck-Cuzit-MbARvlCyCdw-CFL_OkCcz-uxgGGyAOGdDGZFKc4V5Qd_-g67jnEKJVygmCoOVLtT-lnIp5pygf1yGYPOzrPIrmF9lFfbNn9s_kr_bKcDhFrjxA2z-bzKfFl-2ynviwZ0t</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2335470078</pqid></control><display><type>article</type><title>TCD Cerebral Hemodynamic Changes during Moderate‐Intensity Exercise in Older Adults</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Alwatban, Mohammed R. ; Liu, Yumei ; Perdomo, Sophy J. ; Ward, Jaimie L. ; Vidoni, Eric D. ; Burns, Jeffrey M. ; Billinger, Sandra A.</creator><creatorcontrib>Alwatban, Mohammed R. ; Liu, Yumei ; Perdomo, Sophy J. ; Ward, Jaimie L. ; Vidoni, Eric D. ; Burns, Jeffrey M. ; Billinger, Sandra A.</creatorcontrib><description>ABSTRACT
BACKGROUND AND PURPOSE
Exercise plays an important role in supporting overall brain health. However, the mechanisms by which exercise supports brain health are imprecisely defined. Further, brain hemodynamic changes during exercise are not clearly understood, especially in older adults. The primary aim of this study was to compare cerebral blood flow velocity and pulsatility index (PI) during moderate‐intensity exercise between older adults with normal pulsatile flow (normal PI) and older adults with elevated pulsatile flow (elevated PI). Secondary aims were to compare cardiovascular disease risk and cognitive function between individuals with elevated and nonelevated PI.
METHODS
Using transcranial Doppler ultrasound (TCD), middle cerebral artery blood velocity (MCAv) and PI were recorded during the rest and moderate‐intensity exercise. End tidal carbon dioxide (PETCO2) and beat‐to‐beat mean arterial blood pressure were also recorded.
RESULTS
We enrolled 104 older adults into the study. The change in PI was greater in normal PI group (35.5% vs. 21.3%, P = .005). The change in MCAv was similar in both groups (11.6% for normal PI vs. 10.6% for elevated PI; P = .22). There was no significant difference in cardiovascular disease risk between the two groups (P = .77). Individuals with elevated PI performed significantly worse in WAIS‐R Digit Symbol and Trail Making Test A (P = .04 and = .01, respectively).
CONCLUSIONS
The percent increase in PI from rest to moderate‐intensity exercise was attenuated in the older adults with elevated resting PI. Higher resting PI may negatively affect brain health as evidenced by the slower processing speed scores.</description><identifier>ISSN: 1051-2284</identifier><identifier>ISSN: 1552-6569</identifier><identifier>EISSN: 1552-6569</identifier><identifier>DOI: 10.1111/jon.12675</identifier><identifier>PMID: 31750593</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adults ; Aged ; Aged, 80 and over ; aging ; Arterial Pressure - physiology ; Blood flow ; Blood Flow Velocity - physiology ; Blood pressure ; Brain ; Brain - diagnostic imaging ; Brain - physiology ; Carbon dioxide ; Cardiovascular disease ; Cardiovascular diseases ; Cerebral blood flow ; Cerebrovascular Circulation - physiology ; Cognition - physiology ; Cognitive ability ; Doppler effect ; Exercise - physiology ; Female ; Flow velocity ; Health risk assessment ; Health risks ; hemodynamic ; Hemodynamics ; Hemodynamics - physiology ; Humans ; Male ; Middle Cerebral Artery - diagnostic imaging ; Middle Cerebral Artery - physiology ; Neuroimaging ; Neuropsychological Tests ; Older people ; Pulsatile Flow ; pulsatility index ; Transcranial Doppler ultrasound ; Ultrasonography, Doppler, Transcranial ; Ultrasound</subject><ispartof>Journal of neuroimaging, 2020-01, Vol.30 (1), p.76-81</ispartof><rights>2019 by the American Society of Neuroimaging</rights><rights>2019 by the American Society of Neuroimaging.</rights><rights>2020 American Society of Neuroimaging</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4435-80c0b81a02482c37de462871f41c575843e4376538f436b672214169f3c206623</citedby><cites>FETCH-LOGICAL-c4435-80c0b81a02482c37de462871f41c575843e4376538f436b672214169f3c206623</cites><orcidid>0000-0002-1618-7207 ; 0000-0003-0945-4212</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjon.12675$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjon.12675$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31750593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alwatban, Mohammed R.</creatorcontrib><creatorcontrib>Liu, Yumei</creatorcontrib><creatorcontrib>Perdomo, Sophy J.</creatorcontrib><creatorcontrib>Ward, Jaimie L.</creatorcontrib><creatorcontrib>Vidoni, Eric D.</creatorcontrib><creatorcontrib>Burns, Jeffrey M.</creatorcontrib><creatorcontrib>Billinger, Sandra A.</creatorcontrib><title>TCD Cerebral Hemodynamic Changes during Moderate‐Intensity Exercise in Older Adults</title><title>Journal of neuroimaging</title><addtitle>J Neuroimaging</addtitle><description>ABSTRACT
BACKGROUND AND PURPOSE
Exercise plays an important role in supporting overall brain health. However, the mechanisms by which exercise supports brain health are imprecisely defined. Further, brain hemodynamic changes during exercise are not clearly understood, especially in older adults. The primary aim of this study was to compare cerebral blood flow velocity and pulsatility index (PI) during moderate‐intensity exercise between older adults with normal pulsatile flow (normal PI) and older adults with elevated pulsatile flow (elevated PI). Secondary aims were to compare cardiovascular disease risk and cognitive function between individuals with elevated and nonelevated PI.
METHODS
Using transcranial Doppler ultrasound (TCD), middle cerebral artery blood velocity (MCAv) and PI were recorded during the rest and moderate‐intensity exercise. End tidal carbon dioxide (PETCO2) and beat‐to‐beat mean arterial blood pressure were also recorded.
RESULTS
We enrolled 104 older adults into the study. The change in PI was greater in normal PI group (35.5% vs. 21.3%, P = .005). The change in MCAv was similar in both groups (11.6% for normal PI vs. 10.6% for elevated PI; P = .22). There was no significant difference in cardiovascular disease risk between the two groups (P = .77). Individuals with elevated PI performed significantly worse in WAIS‐R Digit Symbol and Trail Making Test A (P = .04 and = .01, respectively).
CONCLUSIONS
The percent increase in PI from rest to moderate‐intensity exercise was attenuated in the older adults with elevated resting PI. Higher resting PI may negatively affect brain health as evidenced by the slower processing speed scores.</description><subject>Adults</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>aging</subject><subject>Arterial Pressure - physiology</subject><subject>Blood flow</subject><subject>Blood Flow Velocity - physiology</subject><subject>Blood pressure</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiology</subject><subject>Carbon dioxide</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cerebral blood flow</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Doppler effect</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Flow velocity</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>hemodynamic</subject><subject>Hemodynamics</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Cerebral Artery - diagnostic imaging</subject><subject>Middle Cerebral Artery - physiology</subject><subject>Neuroimaging</subject><subject>Neuropsychological Tests</subject><subject>Older people</subject><subject>Pulsatile Flow</subject><subject>pulsatility index</subject><subject>Transcranial Doppler ultrasound</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Ultrasound</subject><issn>1051-2284</issn><issn>1552-6569</issn><issn>1552-6569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1OFTEYhidGI4guvAHTxI0sBvrfzsaEDCgY9Gxg3fR0vjn0ZKbFdkY4Oy_Ba-RKqB4kamI3bfI9ffK9eavqNcEHpJzDdQwHhEolnlS7RAhaSyGbp-WNBakp1XynepHzGmNKOGXPqx1GlMCiYbvV5UV7jFpIsEx2QKcwxm4T7Ogdaq9sWEFG3Zx8WKHPsYNkJ7j7_uMsTBCynzbo5BaS8xmQD2gxFAAddfMw5ZfVs94OGV493HvV5YeTi_a0Pl98PGuPzmvHORO1xg4vNbGYck0dUx1wSbUiPSdOKKE5A86UFEz3nMmlVLQEILLpmaNYSsr2qvdb7_W8HKFzEKYSw1wnP9q0MdF68_ck-Cuzit-MbARvlCyCdw-CFL_OkCcz-uxgGGyAOGdDGZFKc4V5Qd_-g67jnEKJVygmCoOVLtT-lnIp5pygf1yGYPOzrPIrmF9lFfbNn9s_kr_bKcDhFrjxA2z-bzKfFl-2ynviwZ0t</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Alwatban, Mohammed R.</creator><creator>Liu, Yumei</creator><creator>Perdomo, Sophy J.</creator><creator>Ward, Jaimie L.</creator><creator>Vidoni, Eric D.</creator><creator>Burns, Jeffrey M.</creator><creator>Billinger, Sandra A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1618-7207</orcidid><orcidid>https://orcid.org/0000-0003-0945-4212</orcidid></search><sort><creationdate>202001</creationdate><title>TCD Cerebral Hemodynamic Changes during Moderate‐Intensity Exercise in Older Adults</title><author>Alwatban, Mohammed R. ; Liu, Yumei ; Perdomo, Sophy J. ; Ward, Jaimie L. ; Vidoni, Eric D. ; Burns, Jeffrey M. ; Billinger, Sandra A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4435-80c0b81a02482c37de462871f41c575843e4376538f436b672214169f3c206623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adults</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>aging</topic><topic>Arterial Pressure - physiology</topic><topic>Blood flow</topic><topic>Blood Flow Velocity - physiology</topic><topic>Blood pressure</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - physiology</topic><topic>Carbon dioxide</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cerebral blood flow</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Doppler effect</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Flow velocity</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>hemodynamic</topic><topic>Hemodynamics</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Cerebral Artery - diagnostic imaging</topic><topic>Middle Cerebral Artery - physiology</topic><topic>Neuroimaging</topic><topic>Neuropsychological Tests</topic><topic>Older people</topic><topic>Pulsatile Flow</topic><topic>pulsatility index</topic><topic>Transcranial Doppler ultrasound</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alwatban, Mohammed R.</creatorcontrib><creatorcontrib>Liu, Yumei</creatorcontrib><creatorcontrib>Perdomo, Sophy J.</creatorcontrib><creatorcontrib>Ward, Jaimie L.</creatorcontrib><creatorcontrib>Vidoni, Eric D.</creatorcontrib><creatorcontrib>Burns, Jeffrey M.</creatorcontrib><creatorcontrib>Billinger, Sandra A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alwatban, Mohammed R.</au><au>Liu, Yumei</au><au>Perdomo, Sophy J.</au><au>Ward, Jaimie L.</au><au>Vidoni, Eric D.</au><au>Burns, Jeffrey M.</au><au>Billinger, Sandra A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TCD Cerebral Hemodynamic Changes during Moderate‐Intensity Exercise in Older Adults</atitle><jtitle>Journal of neuroimaging</jtitle><addtitle>J Neuroimaging</addtitle><date>2020-01</date><risdate>2020</risdate><volume>30</volume><issue>1</issue><spage>76</spage><epage>81</epage><pages>76-81</pages><issn>1051-2284</issn><issn>1552-6569</issn><eissn>1552-6569</eissn><abstract>ABSTRACT
BACKGROUND AND PURPOSE
Exercise plays an important role in supporting overall brain health. However, the mechanisms by which exercise supports brain health are imprecisely defined. Further, brain hemodynamic changes during exercise are not clearly understood, especially in older adults. The primary aim of this study was to compare cerebral blood flow velocity and pulsatility index (PI) during moderate‐intensity exercise between older adults with normal pulsatile flow (normal PI) and older adults with elevated pulsatile flow (elevated PI). Secondary aims were to compare cardiovascular disease risk and cognitive function between individuals with elevated and nonelevated PI.
METHODS
Using transcranial Doppler ultrasound (TCD), middle cerebral artery blood velocity (MCAv) and PI were recorded during the rest and moderate‐intensity exercise. End tidal carbon dioxide (PETCO2) and beat‐to‐beat mean arterial blood pressure were also recorded.
RESULTS
We enrolled 104 older adults into the study. The change in PI was greater in normal PI group (35.5% vs. 21.3%, P = .005). The change in MCAv was similar in both groups (11.6% for normal PI vs. 10.6% for elevated PI; P = .22). There was no significant difference in cardiovascular disease risk between the two groups (P = .77). Individuals with elevated PI performed significantly worse in WAIS‐R Digit Symbol and Trail Making Test A (P = .04 and = .01, respectively).
CONCLUSIONS
The percent increase in PI from rest to moderate‐intensity exercise was attenuated in the older adults with elevated resting PI. Higher resting PI may negatively affect brain health as evidenced by the slower processing speed scores.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31750593</pmid><doi>10.1111/jon.12675</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1618-7207</orcidid><orcidid>https://orcid.org/0000-0003-0945-4212</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1051-2284 |
| ispartof | Journal of neuroimaging, 2020-01, Vol.30 (1), p.76-81 |
| issn | 1051-2284 1552-6569 1552-6569 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6954976 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adults Aged Aged, 80 and over aging Arterial Pressure - physiology Blood flow Blood Flow Velocity - physiology Blood pressure Brain Brain - diagnostic imaging Brain - physiology Carbon dioxide Cardiovascular disease Cardiovascular diseases Cerebral blood flow Cerebrovascular Circulation - physiology Cognition - physiology Cognitive ability Doppler effect Exercise - physiology Female Flow velocity Health risk assessment Health risks hemodynamic Hemodynamics Hemodynamics - physiology Humans Male Middle Cerebral Artery - diagnostic imaging Middle Cerebral Artery - physiology Neuroimaging Neuropsychological Tests Older people Pulsatile Flow pulsatility index Transcranial Doppler ultrasound Ultrasonography, Doppler, Transcranial Ultrasound |
| title | TCD Cerebral Hemodynamic Changes during Moderate‐Intensity Exercise in Older Adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T19%3A01%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TCD%20Cerebral%20Hemodynamic%20Changes%20during%20Moderate%E2%80%90Intensity%20Exercise%20in%20Older%20Adults&rft.jtitle=Journal%20of%20neuroimaging&rft.au=Alwatban,%20Mohammed%20R.&rft.date=2020-01&rft.volume=30&rft.issue=1&rft.spage=76&rft.epage=81&rft.pages=76-81&rft.issn=1051-2284&rft.eissn=1552-6569&rft_id=info:doi/10.1111/jon.12675&rft_dat=%3Cproquest_pubme%3E2335470078%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2335470078&rft_id=info:pmid/31750593&rfr_iscdi=true |