Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

BACKGROUND:Myocardial metabolic impairment is a major feature in chronic heart failure. As the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for enzymes signaling energy stress and oxidative stress response, nicotinamide adenine dinucleotide (NAD) is emerging as a me...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2018-05, Vol.137 (21), p.2256-2273
Hauptverfasser:	Diguet, Nicolas, Trammell, Samuel A.J, Tannous, Cynthia, Deloux, Robin, Piquereau, Jérôme, Mougenot, Nathalie, Gouge, Anne, Gressette, Mélanie, Manoury, Boris, Blanc, Jocelyne, Breton, Marie, Decaux, Jean-François, Lavery, Gareth G, Baczkó, István, Zoll, Joffrey, Garnier, Anne, Li, Zhenlin, Brenner, Charles, Mericskay, Mathias
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - therapeutic use AMP-Activated Protein Kinases - metabolism Animals Biochemistry, Molecular Biology Cardiomyopathy, Dilated - drug therapy Citric Acid - metabolism Cytokines - genetics Cytokines - metabolism Dietary Supplements Disease Models, Animal Gene Expression Profiling Heart Failure - prevention & control Life Sciences Metabolome - drug effects Mice Mice, Transgenic Molecular biology Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism NAD - metabolism Niacinamide - analogs & derivatives Niacinamide - therapeutic use Nicotinamide Phosphoribosyltransferase - genetics Nicotinamide Phosphoribosyltransferase - metabolism Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Piperidines - therapeutic use PPAR alpha - metabolism Rats Serum Response Factor - deficiency Serum Response Factor - genetics
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