Patient-derived xenografts of central nervous system metastasis reveal expansion of aggressive minor clones

Abstract Background The dearth of relevant tumor models reflecting the heterogeneity of human central nervous system metastasis (CM) has hindered development of novel therapies. Methods We established 39 CM patient-derived xenograft (PDX) models representing the histological spectrum, and performed...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2020-01, Vol.22 (1), p.70-83
Hauptverfasser:	Tew, Ben Yi, Legendre, Christophe, Schroeder, Mark A, Triche, Tim, Gooden, Gerald C, Huang, Yizhou, Butry, Loren, Ma, Daniel J, Johnson, Kyle, Martinez, Rae Anne, Pierobon, Mariaelena, Petricoin, Emanuel F, O’shaughnessy, Joyce, Osborne, Cindy, Tapia, Coya, Buckley, David N, Glen, Jennifer, Bernstein, Mark, Sarkaria, Jann N, Toms, Steven A, Salhia, Bodour
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic and Translational Investigations Brain Neoplasms - genetics Brain Neoplasms - secondary Clone Cells Disease Models, Animal Female Heterografts Humans Mice
Online-Zugang:	Volltext
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