Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

Differentiation of proinflammatory CD4+ conventional T cells (Tconv) is critical for productive antitumor responses yet their elicitation remains poorly understood. We comprehensively characterized myeloid cells in tumor draining lymph nodes (tdLN) of mice and identified two subsets of conventional...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2019-04, Vol.177 (3), p.556-571.e16
Hauptverfasser:	Binnewies, Mikhail, Mujal, Adriana M., Pollack, Joshua L., Combes, Alexis J., Hardison, Emily A., Barry, Kevin C., Tsui, Jessica, Ruhland, Megan K., Kersten, Kelly, Abushawish, Marwan A., Spasic, Marko, Giurintano, Jonathan P., Chan, Vincent, Daud, Adil I., Ha, Patrick, Ye, Chun J., Roberts, Edward W., Krummel, Matthew F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antigens Antigens, Neoplasm - immunology CD4+ T cells CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation Cell Line, Tumor checkpoint blockade Cytokines - metabolism dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Diphtheria Toxin - immunology Forkhead Transcription Factors - metabolism Humans immunity immunotherapy Lectins, C-Type - genetics Lectins, C-Type - metabolism lymph nodes Lymph Nodes - immunology Lymph Nodes - metabolism Lymphocyte Activation melanoma Melanoma, Experimental - immunology Melanoma, Experimental - pathology Mice Mice, Inbred C57BL Mice, Knockout patients phenotype Receptors, Chemokine - metabolism regulatory T cells T cell priming T-Lymphocytes, Regulatory - immunology therapeutics traffic tumor immunology Tumor Microenvironment
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!