A Trans-amplifying RNA Vaccine Strategy for Induction of Potent Protective Immunity

Here, we present a potent RNA vaccine approach based on a novel bipartite vector system using trans-amplifying RNA (taRNA). The vector cassette encoding the vaccine antigen originates from an alphaviral self-amplifying RNA (saRNA), from which the replicase was deleted to form a transreplicon. Replic...

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Veröffentlicht in:	Molecular therapy 2020-01, Vol.28 (1), p.119-128
Hauptverfasser:	Beissert, Tim, Perkovic, Mario, Vogel, Annette, Erbar, Stephanie, Walzer, Kerstin C., Hempel, Tina, Brill, Silke, Haefner, Erik, Becker, René, Türeci, Özlem, Sahin, Ugur
Format:	Artikel
Sprache:	eng
Schlagworte:	alphavirus Animals Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antigens Cricetinae Dogs Efficiency Female Genes Genetic Vectors HEK293 Cells Hemagglutinin Glycoproteins, Influenza Virus - immunology Hemagglutinins Humans Immune response Immunogenicity, Vaccine Influenza Influenza A Virus, H1N1 Subtype - immunology influenza vaccine Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - metabolism Influenza, Human - virology Madin Darby Canine Kidney Cells Mice Mice, Inbred BALB C mRNA mRNA vaccines Original Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Proteins Replicase replicon RNA polymerase RNA vaccine RNA, Viral - genetics saRNA Semliki forest virus - genetics taRNA trans-replication Vaccination vaccine Vaccines Viral Replicase Complex Proteins - genetics Viruses
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