The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A

The calcium-activated chloride channel TMEM16A is involved in many physiological processes, and insufficient function of TMEM16A may lead to the occurrence of various diseases. Therefore, TMEM16A activators are supposed to be potentially useful for treatment of TMEM16A downregulation-inducing diseas...

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Veröffentlicht in:	Biophysical journal 2020-01, Vol.118 (1), p.262-272
Hauptverfasser:	Guo, Shuai, Chen, Yafei F., Shi, Sai, Pang, Chunli L., Wang, Xuzhao Z., Zhang, Hailin L., Zhan, Yong, An, Hailong L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anoctamin-1 - chemistry Anoctamin-1 - metabolism Binding Sites CHO Cells Cricetulus Dose-Response Relationship, Drug Ginsenosides - chemistry Ginsenosides - metabolism Ginsenosides - pharmacology Guinea Pigs Hydrophobic and Hydrophilic Interactions Models, Molecular Protein Conformation Static Electricity
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