Beta-Aminoisobutyric Acid Inhibits Hypothalamic Inflammation by Reversing Microglia Activation

Beta-aminoisobutyric acid (BAIBA), a natural thymine catabolite, is involved in the beneficial effects of exercise on metabolic disorders. In particular, it has been reported to reverse the inflammatory processes observed in the peripheral organs of animal models of obesity. Therefore, this study ai...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2019-12, Vol.8 (12), p.1609
Hauptverfasser:	Park, Byong Seo, Tu, Thai Hien, Lee, Hannah, Jeong, Da Yeon, Yang, Sunggu, Lee, Byung Ju, Kim, Jae Geun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Aminoisobutyric Acids - administration & dosage Aminoisobutyric Acids - pharmacology Animal models Animals Antibodies Body weight gain Brain research Cell Line Cytokines - genetics Cytokines - immunology Diet Diet, High-Fat - adverse effects Disease Models, Animal Drinking water Encephalitis - chemically induced Encephalitis - drug therapy Encephalitis - immunology Energy metabolism Energy Metabolism - drug effects Exercise Fatty acids Gene expression High fat diet Humans Hypothalamus Hypothalamus - drug effects Hypothalamus - immunology Inflammation Laboratories Male Metabolic disorders Metabolism Mice Microglia Microglia - drug effects Microglia - immunology Nutrition research Obesity Obesity - chemically induced Obesity - complications Obesity - drug therapy Palmitic acid Palmitic Acid - adverse effects Physical fitness Thymine
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