Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy

Aflatoxin B1 (AFB1) is a potent hepatocarcinogen in humans and exposure to AFB1 is known to cause both acute and chronic hepatocellular injury. As the liver is known to be the main target organ of aflatoxin, it is important to identify the key molecules that participate in AFB1-induced hepatotoxicit...

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Veröffentlicht in:	Cell death & disease 2020-01, Vol.11 (1), p.6, Article 6
Hauptverfasser:	Xu, Qingqiang, Shi, Wenwen, Lv, Pan, Meng, Wenqi, Mao, Guanchao, Gong, Chuchu, Chen, Yongchun, Wei, Youheng, He, Xiaowen, Zhao, Jie, Han, Hua, Sun, Mingxue, Xiao, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 14/19 42/89 631/80/82/23 631/80/86/2366 692/699/1503/1607/2749 82/80 96/109 96/2 96/31 96/95 Aflatoxin B1 Aflatoxin B1 - toxicity AKT protein Antibodies Antioxidants Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Biochemistry Biomedical and Life Sciences Caveolin Caveolin 1 - metabolism Caveolin-1 Cell Biology Cell Culture Cell Line Cell Survival - drug effects Cell viability Epidermal growth factor receptors ErbB Receptors - metabolism Hepatotoxicity Humans Immunology Kelch-Like ECH-Associated Protein 1 - metabolism Life Sciences Liver Liver - drug effects Liver - pathology NF-E2-Related Factor 2 - metabolism Oxidation Oxidation-Reduction - drug effects Oxidative stress Oxidative Stress - drug effects Phagocytosis Phosphatidylinositol 3-Kinases - metabolism Signal transduction Signal Transduction - drug effects TOR protein TOR Serine-Threonine Kinases - metabolism Transcription, Genetic - drug effects
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