A high throughput zebrafish chemical screen reveals ALK5 and non-canonical androgen signalling as modulators of the pkd2−/− phenotype

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of end-stage renal failure in humans and results from germline mutations in PKD1 or PKD2 . Despite the recent approval of tolvaptan, safer and more effective alternative drugs are clearly needed to slow disease p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2020-01, Vol.10 (1), p.72-72, Article 72
Hauptverfasser:	Metzner, A., Griffiths, J. D., Streets, A. J., Markham, E., Philippou, T., Van Eeden, F. J. M., Ong, A. C. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/1425 64 64/116 692/4022/1585/1589 Androgen receptors Androgens Animals Animals, Genetically Modified - metabolism Apoptosis - drug effects Danio rerio Dogs Drug development Embryo, Nonmammalian - drug effects Embryo, Nonmammalian - metabolism Embryos End-stage renal disease Flavonoids Genotype & phenotype High-Throughput Screening Assays Humanities and Social Sciences Humans Kidney diseases Madin Darby Canine Kidney Cells multidisciplinary Mutants Phenotype Phenotypes Polycystic kidney Polycystic Kidney, Autosomal Dominant - metabolism Polycystic Kidney, Autosomal Dominant - pathology Receptor, Transforming Growth Factor-beta Type I - antagonists & inhibitors Receptor, Transforming Growth Factor-beta Type I - metabolism Receptors, Androgen - metabolism Renal failure Science Science (multidisciplinary) Signal transduction Signal Transduction - drug effects Small Molecule Libraries - chemistry Small Molecule Libraries - metabolism Small Molecule Libraries - pharmacology Steroid hormones Therapeutic applications TRPP Cation Channels - deficiency TRPP Cation Channels - genetics TRPP Cation Channels - metabolism Zebrafish Zebrafish Proteins - deficiency Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!