Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature
A 70-year-old woman was referred to our hospital due to symptoms of dry eyes, dry mouth, and epigastric pain. Computed tomography showed distal pancreatic swelling, liver edge dullness and surface irregularities. Serum anti-nuclear antibody titers, immunoglobulin G and IgG4 levels were elevated. Aut...
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| Veröffentlicht in: | Internal Medicine 2019/12/15, Vol.58(24), pp.3537-3543 |
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| container_title | Internal Medicine |
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| creator | Matsumoto, Kotaro Kikuchi, Kentaro Kuniyoshi, Noriyuki Tsunashima, Hiromichi Sekine, Katsunori Mabuchi, Masatoshi Doi, Shinpei Zen, Yoh Miyakawa, Hiroshi |
| description | A 70-year-old woman was referred to our hospital due to symptoms of dry eyes, dry mouth, and epigastric pain. Computed tomography showed distal pancreatic swelling, liver edge dullness and surface irregularities. Serum anti-nuclear antibody titers, immunoglobulin G and IgG4 levels were elevated. Autoimmune pancreatitis (AIP) was diagnosed based on endoscopic findings and a histopathological examination. Her AIP improved after starting prednisolone treatment. A liver biopsy revealed interface hepatitis with lymphoplasmacyte and IgG4-positive plasma cell infiltration. In addition, non-alcoholic steatohepatitis (NASH) was diagnosed based on the presence of parenchymal steatosis, ballooning hepatocytes, and pericellular fibrosis. We experienced a unique liver disease case showing IgG4-related liver disease overlapping with NASH. |
| doi_str_mv | 10.2169/internalmedicine.3204-19 |
| format | Article |
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Computed tomography showed distal pancreatic swelling, liver edge dullness and surface irregularities. Serum anti-nuclear antibody titers, immunoglobulin G and IgG4 levels were elevated. Autoimmune pancreatitis (AIP) was diagnosed based on endoscopic findings and a histopathological examination. Her AIP improved after starting prednisolone treatment. A liver biopsy revealed interface hepatitis with lymphoplasmacyte and IgG4-positive plasma cell infiltration. In addition, non-alcoholic steatohepatitis (NASH) was diagnosed based on the presence of parenchymal steatosis, ballooning hepatocytes, and pericellular fibrosis. We experienced a unique liver disease case showing IgG4-related liver disease overlapping with NASH.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.3204-19</identifier><identifier>PMID: 31366800</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adult ; Aged ; Antibodies, Antinuclear - blood ; autoimmune hepatitis ; autoimmune pancreatitis ; Autoimmune Pancreatitis - complications ; Autoimmune Pancreatitis - diagnosis ; Balloon treatment ; Biopsy ; Blood Chemical Analysis ; Case Report ; Computed tomography ; Female ; Fibrosis ; Hepatitis ; Hepatitis - complications ; Hepatitis - pathology ; Hepatocytes ; Humans ; IgG4-related disease ; Immunoglobulin G ; Immunoglobulin G - blood ; Immunoglobulin G4 ; Immunoglobulins ; Internal medicine ; Literature reviews ; Liver ; Liver - diagnostic imaging ; Liver - pathology ; Liver diseases ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - pathology ; non-alcoholic steatohepatitis ; overlap ; Pancreas ; Pancreas - pathology ; Pancreatitis ; Prednisolone ; Prednisolone - therapeutic use ; Steatosis ; Tomography, X-Ray Computed</subject><ispartof>Internal Medicine, 2019/12/15, Vol.58(24), pp.3537-3543</ispartof><rights>2019 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><rights>Copyright © 2019 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-3c5873c60456ffcd057c67d0bcbd7b49d9430b89b7c16766413b549b9a910763</citedby><cites>FETCH-LOGICAL-c610t-3c5873c60456ffcd057c67d0bcbd7b49d9430b89b7c16766413b549b9a910763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949448/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949448/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31366800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, Kotaro</creatorcontrib><creatorcontrib>Kikuchi, Kentaro</creatorcontrib><creatorcontrib>Kuniyoshi, Noriyuki</creatorcontrib><creatorcontrib>Tsunashima, Hiromichi</creatorcontrib><creatorcontrib>Sekine, Katsunori</creatorcontrib><creatorcontrib>Mabuchi, Masatoshi</creatorcontrib><creatorcontrib>Doi, Shinpei</creatorcontrib><creatorcontrib>Zen, Yoh</creatorcontrib><creatorcontrib>Miyakawa, Hiroshi</creatorcontrib><title>Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 70-year-old woman was referred to our hospital due to symptoms of dry eyes, dry mouth, and epigastric pain. Computed tomography showed distal pancreatic swelling, liver edge dullness and surface irregularities. Serum anti-nuclear antibody titers, immunoglobulin G and IgG4 levels were elevated. Autoimmune pancreatitis (AIP) was diagnosed based on endoscopic findings and a histopathological examination. Her AIP improved after starting prednisolone treatment. A liver biopsy revealed interface hepatitis with lymphoplasmacyte and IgG4-positive plasma cell infiltration. In addition, non-alcoholic steatohepatitis (NASH) was diagnosed based on the presence of parenchymal steatosis, ballooning hepatocytes, and pericellular fibrosis. We experienced a unique liver disease case showing IgG4-related liver disease overlapping with NASH.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Antinuclear - blood</subject><subject>autoimmune hepatitis</subject><subject>autoimmune pancreatitis</subject><subject>Autoimmune Pancreatitis - complications</subject><subject>Autoimmune Pancreatitis - diagnosis</subject><subject>Balloon treatment</subject><subject>Biopsy</subject><subject>Blood Chemical Analysis</subject><subject>Case Report</subject><subject>Computed tomography</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Hepatitis</subject><subject>Hepatitis - complications</subject><subject>Hepatitis - pathology</subject><subject>Hepatocytes</subject><subject>Humans</subject><subject>IgG4-related disease</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G4</subject><subject>Immunoglobulins</subject><subject>Internal medicine</subject><subject>Literature reviews</subject><subject>Liver</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-alcoholic Fatty Liver Disease - complications</subject><subject>Non-alcoholic Fatty Liver Disease - pathology</subject><subject>non-alcoholic steatohepatitis</subject><subject>overlap</subject><subject>Pancreas</subject><subject>Pancreas - pathology</subject><subject>Pancreatitis</subject><subject>Prednisolone</subject><subject>Prednisolone - therapeutic use</subject><subject>Steatosis</subject><subject>Tomography, X-Ray Computed</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUtGOEyEUnRiNW6u_YEh88WVWGBhm8MGkqbpu0ljjNvGRMMxth4ZCBaab_Tz_TJrWRtcXLoRzzj1cTlEggq8rwsU74xIEp-wOeqONg2taYVYS8aSYEMpE2VS0flpMsCBtWeXlqngR4xZj2jaiel5cUUI5bzGeFL9ud7vR-Y313WiNQzesDGBVgh4tzAEC-mgiqAhomQ9W7ffGbdC9SQP66l2prPaDt0ajuwQq-QH2KplkIloNKqEfKma-2jgfs96d2Y02KQd-jPbhJDIbkzdHB4C-KacDnOjv0QzNj12_w96HhJTr8_Zg4B75NUoDZHN5AiqNAV4Wz9bKRnh1rtNi9fnTav6lXCxvbuezRak5wamkum4bqjlmNV-vdY_rRvOmx53u-qZjoheM4q4VXaMJbzhnhHY1E51QguCG02nx4SS7H7s8dg0uBWXlPpidCg_SKyP_vXFmkBt_kFwwwVibBd6eBYL_OUJMcmeiBmtPE5FVxZuGZY84Q988gm79ePzvjKKUsJrVuU6L9oTSwccYYH0xQ7A8xkQ-jok8xkQSkamv_37MhfgnFxmwPAG2MakNXAAqJKMt_K9ct7Jix_Xc4oLUgwoSHP0Nt8jgkw</recordid><startdate>20191215</startdate><enddate>20191215</enddate><creator>Matsumoto, Kotaro</creator><creator>Kikuchi, Kentaro</creator><creator>Kuniyoshi, Noriyuki</creator><creator>Tsunashima, Hiromichi</creator><creator>Sekine, Katsunori</creator><creator>Mabuchi, Masatoshi</creator><creator>Doi, Shinpei</creator><creator>Zen, Yoh</creator><creator>Miyakawa, Hiroshi</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191215</creationdate><title>Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature</title><author>Matsumoto, Kotaro ; Kikuchi, Kentaro ; Kuniyoshi, Noriyuki ; Tsunashima, Hiromichi ; Sekine, Katsunori ; Mabuchi, Masatoshi ; Doi, Shinpei ; Zen, Yoh ; Miyakawa, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-3c5873c60456ffcd057c67d0bcbd7b49d9430b89b7c16766413b549b9a910763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Antinuclear - blood</topic><topic>autoimmune hepatitis</topic><topic>autoimmune pancreatitis</topic><topic>Autoimmune Pancreatitis - complications</topic><topic>Autoimmune Pancreatitis - diagnosis</topic><topic>Balloon treatment</topic><topic>Biopsy</topic><topic>Blood Chemical Analysis</topic><topic>Case Report</topic><topic>Computed tomography</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Hepatitis</topic><topic>Hepatitis - complications</topic><topic>Hepatitis - pathology</topic><topic>Hepatocytes</topic><topic>Humans</topic><topic>IgG4-related disease</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G4</topic><topic>Immunoglobulins</topic><topic>Internal medicine</topic><topic>Literature reviews</topic><topic>Liver</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - pathology</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-alcoholic Fatty Liver Disease - complications</topic><topic>Non-alcoholic Fatty Liver Disease - pathology</topic><topic>non-alcoholic steatohepatitis</topic><topic>overlap</topic><topic>Pancreas</topic><topic>Pancreas - pathology</topic><topic>Pancreatitis</topic><topic>Prednisolone</topic><topic>Prednisolone - therapeutic use</topic><topic>Steatosis</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, Kotaro</creatorcontrib><creatorcontrib>Kikuchi, Kentaro</creatorcontrib><creatorcontrib>Kuniyoshi, Noriyuki</creatorcontrib><creatorcontrib>Tsunashima, Hiromichi</creatorcontrib><creatorcontrib>Sekine, Katsunori</creatorcontrib><creatorcontrib>Mabuchi, Masatoshi</creatorcontrib><creatorcontrib>Doi, Shinpei</creatorcontrib><creatorcontrib>Zen, Yoh</creatorcontrib><creatorcontrib>Miyakawa, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, Kotaro</au><au>Kikuchi, Kentaro</au><au>Kuniyoshi, Noriyuki</au><au>Tsunashima, Hiromichi</au><au>Sekine, Katsunori</au><au>Mabuchi, Masatoshi</au><au>Doi, Shinpei</au><au>Zen, Yoh</au><au>Miyakawa, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2019-12-15</date><risdate>2019</risdate><volume>58</volume><issue>24</issue><spage>3537</spage><epage>3543</epage><pages>3537-3543</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 70-year-old woman was referred to our hospital due to symptoms of dry eyes, dry mouth, and epigastric pain. Computed tomography showed distal pancreatic swelling, liver edge dullness and surface irregularities. Serum anti-nuclear antibody titers, immunoglobulin G and IgG4 levels were elevated. Autoimmune pancreatitis (AIP) was diagnosed based on endoscopic findings and a histopathological examination. Her AIP improved after starting prednisolone treatment. A liver biopsy revealed interface hepatitis with lymphoplasmacyte and IgG4-positive plasma cell infiltration. In addition, non-alcoholic steatohepatitis (NASH) was diagnosed based on the presence of parenchymal steatosis, ballooning hepatocytes, and pericellular fibrosis. We experienced a unique liver disease case showing IgG4-related liver disease overlapping with NASH.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>31366800</pmid><doi>10.2169/internalmedicine.3204-19</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal Medicine, 2019/12/15, Vol.58(24), pp.3537-3543 |
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| source | J-STAGE Free; MEDLINE; PubMed Central; PubMed Central Open Access |
| subjects | Adult Aged Antibodies, Antinuclear - blood autoimmune hepatitis autoimmune pancreatitis Autoimmune Pancreatitis - complications Autoimmune Pancreatitis - diagnosis Balloon treatment Biopsy Blood Chemical Analysis Case Report Computed tomography Female Fibrosis Hepatitis Hepatitis - complications Hepatitis - pathology Hepatocytes Humans IgG4-related disease Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G4 Immunoglobulins Internal medicine Literature reviews Liver Liver - diagnostic imaging Liver - pathology Liver diseases Male Middle Aged Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - pathology non-alcoholic steatohepatitis overlap Pancreas Pancreas - pathology Pancreatitis Prednisolone Prednisolone - therapeutic use Steatosis Tomography, X-Ray Computed |
| title | Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature |
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