SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond

Research of the past view years expanded our understanding of the various physiological functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis, reprogramming, and cancer. However, while scientific reports featuring novel and exciting aspects of SOX2-driven biology are pu...

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Veröffentlicht in:	Oncogene 2020-01, Vol.39 (2), p.278-292
Hauptverfasser:	Schaefer, Thorsten, Lengerke, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 631/532 631/80/458 Acetylation AKT protein Apoptosis Biochemistry Cancer Cell Biology Cell Proliferation - genetics Cellular Reprogramming Development and progression Elafin - genetics Fulvestrant Glycosylation Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Methylation Neoplasms - genetics Neoplasms - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncogene Protein v-akt - genetics Oncology Phosphorylation Protein Processing, Post-Translational - genetics Proteins Review Review Article Signal Transduction - genetics Sox2 protein SOXB1 Transcription Factors - genetics SUMO protein Ubiquitination
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