Synaptic Dysfunction in Human Neurons With Autism-Associated Deletions in PTCHD1-AS

The Xp22.11 locus that encompasses PTCHD1, DDX53, and the long noncoding RNA PTCHD1-AS is frequently disrupted in male subjects with autism spectrum disorder (ASD), but the functional consequences of these genetic risk factors for ASD are unknown. To evaluate the functional consequences of PTCHD1 lo...

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Veröffentlicht in:	Biological psychiatry (1969) 2020-01, Vol.87 (2), p.139-149
Hauptverfasser:	Ross, P. Joel, Zhang, Wen-Bo, Mok, Rebecca S.F., Zaslavsky, Kirill, Deneault, Eric, D’Abate, Lia, Rodrigues, Deivid C., Yuen, Ryan K.C., Faheem, Muhammad, Mufteev, Marat, Piekna, Alina, Wei, Wei, Pasceri, Peter, Landa, Rebecca J., Nagy, Andras, Varga, Balazs, Salter, Michael W., Scherer, Stephen W., Ellis, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Autism spectrum disorder Autism Spectrum Disorder - genetics Autistic Disorder - genetics Excitatory synapses Genetics Humans Induced Pluripotent Stem Cells Long noncoding RNA Male Membrane Proteins Neurons Synapses
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