Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial

Ramucirumab—an IgG1 vascular endothelial growth factor receptor 2 antagonist—plus docetaxel was previously reported to improve progression-free survival in platinum-refractory, advanced urothelial carcinoma. Here, we report the secondary endpoint of overall survival results for the RANGE trial. We d...

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Veröffentlicht in:	The lancet oncology 2020-01, Vol.21 (1), p.105-120
Hauptverfasser:	Petrylak, Daniel P, de Wit, Ronald, Chi, Kim N, Drakaki, Alexandra, Sternberg, Cora N, Nishiyama, Hiroyuki, Castellano, Daniel, Hussain, Syed A, Fléchon, Aude, van der Heijden, Michiel S, Matsubara, Nobuaki, Necchi, Andrea, Géczi, Lajos, Ou, Yen-Chuan, Coskun, Hasan Senol, Su, Wen-Pin, Percent, Ivor J, Lee, Jae-Lyun, Laestadius, Fredrik, Peer, Avivit, Garcia del Muro, Xavier, Cicin, Irfan, Vaishampayan, Ulka, Aragon-Ching, Jeanny B, Hamid, Oday, Wijayawardana, Sameera, Russo, Francesca, Zimmermann, Annamaria H, Bell-McGuinn, Katherine M, Wong, Suet-Lai Shirley, Tan, Thean Hsiang, Hovey, Elizabeth Jane, Clay, Timothy Dudley, Wan Ng, Siobhan Su, Rutten, Annemie, Dumez, Herlinde, Ferrario, Cristiano, Sengeloev, Lisa, Jensen, Niels Viggo, Thibault, Constance, Laguerre, Brigitte, Joly, Florence, Culine, Stéphane, Becht, Catherine, Niegisch, Günter, Stöckle, Michael, Grimm, Marc-Oliver, Schultze-Seemann, Wolfgang, Kalofonos, Haralambos, Mavroudis, Dimitrios, Karavasilis, Vasilis, Révész, Janos, Leibowitz-Amit, Raya, Kejzman, Daniel, Sarid, David, Massari, Francesco, Osawa, Takahiro, Miyajima, Naoto, Shinohara, Nobuo, Fukuta, Fumimasa, Ohyama, Chikara, Obara, Wataru, Yamashita, Shinichi, Tomita, Yoshihiko, Kawai, Koji, Oyama, Masafumi, Yonese, Junji, Uemura, Motohide, Tsunemori, Hiroyuki, Yokomizo, Akira, Nagamori, Satoshi, Lee, Hyo Jin, Park, Se Hoon, Rha, Sun Young, Kim, Yu Jung, Lee, Yun-Gyoo, Vazquez Cortés, Leticia, Lorena Urzua Flores, Claudia, Blaisse, Reinoud J.B., Aarts, Maureen J.B., Schenker, Michael, Herzal, Alina Amalia, Udrea, Anghel Adrian, Karlov, Petr, Fomkin, Roman, Grande, Enrique, Lin, Chia-Chi, Yeh, Su-Peng, Erman, Mustafa, Urun, Yuksel, Golovko, Yuriy, Sinielnikov, Ivan, Crabb, Simon J., Syndikus, Isabel, Sundar, Santhanam, Pan, Chong Xian, Schwarz, James K., Acs, Peter Istvan, Hainsworth, John D., Lawler, William Eyre
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angina pectoris Antibodies, Monoclonal, Humanized - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bladder cancer Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - secondary Chemotherapy Docetaxel - administration & dosage Double-Blind Method Double-blind studies Female Follow-Up Studies Humans Immune checkpoint inhibitors Immunoglobulin G Immunotherapy Intravenous administration Laboratories Ligands Male Medical prognosis Metastases Metastasis Middle Aged Monoclonal antibodies Neoplasm Invasiveness Neoplasm Metastasis Neutropenia Oncology Patients Platinum Platinum - administration & dosage Population studies Prognosis Quality of life Ramucirumab Salvage Therapy Sensitivity analysis Studies Survival Survival analysis Survival Rate Targeted cancer therapy Toxicity Urologic Neoplasms - drug therapy Urologic Neoplasms - mortality Urologic Neoplasms - pathology Urothelial carcinoma Vascular endothelial growth factor Vascular endothelial growth factor receptor 2
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