High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis

OBJECTIVEWe examined whether plasma β-amyloid (Aβ)42/Aβ40, as measured by a high-precision assay, accurately diagnosed brain amyloidosis using amyloid PET or CSF p-tau181/Aβ42 as reference standards. METHODSUsing an immunoprecipitation and liquid chromatography–mass spectrometry assay, we measured A...

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Veröffentlicht in:	Neurology 2019-10, Vol.93 (17), p.e1647-e1659
Hauptverfasser:	Schindler, Suzanne E, Bollinger, James G, Ovod, Vitaliy, Mawuenyega, Kwasi G, Li, Yan, Gordon, Brian A, Holtzman, David M, Morris, John C, Benzinger, Tammie L.S, Xiong, Chengjie, Fagan, Anne M, Bateman, Randall J
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Amyloid beta-Peptides - blood Amyloid beta-Peptides - cerebrospinal fluid Amyloidosis - blood Amyloidosis - diagnostic imaging Amyloidosis - genetics Apolipoprotein E4 - genetics Biomarkers - blood Brain - diagnostic imaging Brain - metabolism Female Humans Longitudinal Studies Male Middle Aged Peptide Fragments - blood Peptide Fragments - cerebrospinal fluid Positron-Emission Tomography Prognosis tau Proteins - cerebrospinal fluid
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