Analysis of the CYP1A1 mRNA Dose-Response in Human Keratinocytes Indicates that Relative Potencies of Dioxins, Furans, and PCBs Are Species and Congener Specific

Reports indicate that toxic equivalency factors (TEFs) based primarily on rodent data do not accurately predict in vitro human responsiveness to certain dioxin-like chemicals (DLCs). To investigate this in cells responsive to dioxins and relevant to chloracne, normal human epidermal keratinocytes we...

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Veröffentlicht in:	Toxicological sciences 2010-12, Vol.118 (2), p.704-715
Hauptverfasser:	Sutter, Carrie H., Bodreddigari, Sridevi, Sutter, Thomas R., Carlson, Erik A., Silkworth, Jay B.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,3',4,4',5-Pentachlorobiphenyl Animals Benzofurans - toxicity Cell Line, Tumor Cell Survival - drug effects chloracne Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Dioxins - toxicity Dose-Response Relationship, Drug Environmental Pollutants - toxicity Gene Expression Regulation, Enzymologic - drug effects human human health risk assessment Humans keratinocyte Keratinocytes - drug effects Keratinocytes - metabolism PCB Polychlorinated Biphenyls - toxicity Rats Risk Assessment RNA, Messenger - metabolism Species Specificity TCDD threshold toxic equivalency factor
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