Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma

The identification of a heritable tumor predisposition often leads to changes in management and increased surveillance of individuals who are at risk; however, for many rare entities, our knowledge of heritable predisposition is incomplete. Families with childhood medulloblastoma, one of the most pr...

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Veröffentlicht in:	Journal of clinical oncology 2020-01, Vol.38 (1), p.43-50
Hauptverfasser:	Begemann, Matthias, Waszak, Sebastian M, Robinson, Giles W, Jäger, Natalie, Sharma, Tanvi, Knopp, Cordula, Kraft, Florian, Moser, Olga, Mynarek, Martin, Guerrini-Rousseau, Lea, Brugieres, Laurence, Varlet, Pascale, Pietsch, Torsten, Bowers, Daniel C, Chintagumpala, Murali, Sahm, Felix, Korbel, Jan O, Rutkowski, Stefan, Eggermann, Thomas, Gajjar, Amar, Northcott, Paul, Elbracht, Miriam, Pfister, Stefan M, Kontny, Udo, Kurth, Ingo
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - genetics Brain Neoplasms - metabolism Child Child, Preschool Cohort Studies DNA Methylation Female Genetic Predisposition to Disease Germ-Line Mutation Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Heterozygote Humans Infant Life Sciences Medulloblastoma - genetics Medulloblastoma - metabolism ORIGINAL REPORTS Prospective Studies Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction Whole Exome Sequencing
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