N-acetylcysteine Decreases Fibrosis and Increases Force-Generating Capacity of mdx Diaphragm

Respiratory muscle weakness occurs due to dystrophin deficiency in Duchenne muscular dystrophy (DMD). The mouse model of DMD shows evidence of impaired respiratory muscle performance with attendant inflammation and oxidative stress. We examined the effects of N-acetylcysteine (NAC) supplementation o...

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Veröffentlicht in:	Antioxidants 2019-11, Vol.8 (12), p.581
Hauptverfasser:	Burns, David P, Drummond, Sarah E, Bolger, Dearbhla, Coiscaud, Amélie, Murphy, Kevin H, Edge, Deirdre, O'Halloran, Ken D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Anesthesia Animals Antioxidants Atmospheric pressure Collagen Cytokines Diaphragm Diaphragm (Anatomy) Drinking water Duchenne's muscular dystrophy Dystrophin Electromyography Fibrosis Gene expression Glutathione Hypoxia IL-1β Infiltration Inflammation Interleukin 6 Lipid peroxidation Muscle function Muscle strength Musculoskeletal system Oxidative stress Pulse oximetry Respiration Respiratory system Rodents Sleep Structure-function relationships Supplements Tumor necrosis factor-TNF University colleges
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