Taurochenodeoxycholic Acid Inhibited AP-1 Activation via Stimulating Glucocorticoid Receptor

Taurochenodeoxycholic acid (TCDCA) as a primary bioactive substance of animal bile has been shown to exert good anti-inflammatory and immunomodulatory functions in adjuvant arthritis in rats. The anti-inflammatory and immunomodulatory properties of TCDCA have exhibited interesting similarities with...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2019-12, Vol.24 (24), p.4513
Hauptverfasser:	Li, Lei, Liu, Chang, Mao, Wei, Tumen, Bayaer, Li, Peifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Activation Animals Arthritis Bile Cell Survival - drug effects Crosstalk Cytokines Cytotoxicity Destruction Glucocorticoids IL-1β Inflammation Interleukin 6 Joints (anatomy) Ligands Male Molecular Structure NF-κB protein Phosphorylation Phosphorylation - drug effects Protein Binding Proteins Proto-Oncogene Proteins c-fos - metabolism Rats Receptors, Glucocorticoid - agonists Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Rheumatoid arthritis SOCS-3 protein Taurochenodeoxycholic Acid - chemistry Taurochenodeoxycholic Acid - pharmacology Transcription Factor AP-1 - antagonists & inhibitors Transcription Factor AP-1 - metabolism Transcription factors Transcriptional Activation - drug effects Tumor necrosis factor-TNF Tumor necrosis factor-α
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