Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line

Glioblastoma (GBM) is the most frequent and highest-grade brain tumor in adults. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy, and chemotherapy. The development of more efficient drugs without noticeable side effects is urgent. Co...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2019-12, Vol.24 (24), p.4498
Hauptverfasser:	M Franco, Yollanda E, Y Okubo, Marcia, D Torre, Adriana, P Paiva, Paula, N Rosa, Marcela, O Silva, Viviane A, M Reis, Rui, T G Ruiz, Ana L, M Imamura, Paulo, de Carvalho, João E, B Longato, Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Aquatic plants BAX protein Brain cancer Breast cancer Cancer therapies Cell cycle Cell Cycle Checkpoints - drug effects Cell death Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cervical cancer Cervix Cyclin D1 Cyclin-dependent kinase Cytotoxicity Deoxyribonucleic acid Depolarization Diterpenes Diterpenes - chemistry Diterpenes - pharmacology DNA Evaluation G1 phase Glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Glioma cells Hepatocellular carcinoma Humans Hydrogen peroxide Inflammation Kinases Lung cancer Medical prognosis Membrane potential Mitochondria Mortality Natural products Oral cancer Organic chemistry Phosphorylation - drug effects Prostate Protein kinase Proteins Reactive Oxygen Species - chemistry Rhizomes Tumor cell lines Tumors Zingiberaceae - chemistry
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