Endoscopic Variceal Sequential Ligation Does Not Increase Risk of Gastroesophageal Reflux Disease in Cirrhosis Patients
Background Endoscopic variceal sequential ligation (EVSL) is currently endorsed in our hospital, as the preferred endoscopic treatment for prevention of variceal rebleeding and achieving adequate hemostasis. There is currently a lack of consensus surrounding EVSL-induced changes in esophageal motor...
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| Veröffentlicht in: | Digestive diseases and sciences 2020-01, Vol.65 (1), p.329-335 |
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| creator | Tao, Jin Li, JianZhong Chen, XiaoLiang Guo, YunWei Tian, Hong Wei, XiuQing Zheng, FengPing Wen, ZhuoFu Wu, Bin |
| description | Background
Endoscopic variceal sequential ligation (EVSL) is currently endorsed in our hospital, as the preferred endoscopic treatment for prevention of variceal rebleeding and achieving adequate hemostasis. There is currently a lack of consensus surrounding EVSL-induced changes in esophageal motor function and abnormal reflux.
Aims
To explore alterations in esophageal motor function and risk of abnormal gastroesophageal reflux in liver cirrhosis patients with esophageal varices, after EVSL.
Methods
Twenty-one liver cirrhosis patients with esophageal varices were studied using manometry and 24-h pH monitoring 1 day prior to and 1 month following EVSL. The EVSL consisted of performing esophageal variceal ligation using a multi-band ligator, which was repeated every 4 weeks until the varices were eradicated.
Results
The amplitude and duration of peristaltic contraction waves and the percentage of abnormal esophageal contraction waveforms were unaltered in both the proximal (
P
> 0.05) and the distal (
P
> 0.05) esophagus after EVSL. However, the lower esophageal sphincter pressure was decreased following EVSL (16.1 ± 7.9 mmHg
vs
21.1 ± 6.3 mmHg (
P |
| doi_str_mv | 10.1007/s10620-019-05740-1 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6943406</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712935456</galeid><sourcerecordid>A712935456</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-a87f61059fa832719ef0db561d5d0b13da3b89c96b10d705838099eaf8a42bbb3</originalsourceid><addsrcrecordid>eNp9kktv1DAUhS0EotOBP8ACWWLDJsXXjp14g1RNH1QaASqPreU4TsYlYw92wuPf43RKSxFCXtjy_c65ulcHoWdAjoCQ6lUCIigpCMiC8KokBTxAC-AVKygX9UO0ICDyG0AcoMOUrgghsgLxGB0wYIwKyhfo-6lvQzJh5wz-rKMzVg_4g_06WT-6_Fy7Xo8ueHwSbMJvw4gvvIlWJ4svXfqCQ4fPdRpjrobdRvez_NJ2w_QDn7h0zTmPVy7GTUgu4ffZLVunJ-hRp4dkn97cS_Tp7PTj6k2xfnd-sTpeF4aXMBa6rjoBhMtO14xWIG1H2oYLaHlLGmCtZk0tjRQNkLYivGY1kdLqrtYlbZqGLdHrve9uara2Nbl31IPaRbfV8acK2qn7Fe82qg_flJAlK4nIBi9vDGLIW0mj2rpk7DBob8OUFGWspCBmfIle_IVehSn6PJ6iVICUrOL8jur1YJXzXch9zWyqjiugkvGSz22P_kHl09qtM8HbzuX_ewK6F5gYUoq2u50RiJrjovZxUTku6jouCrLo-Z_buZX8zkcG2B5IueR7G-9G-o_tL_AxyuI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261993755</pqid></control><display><type>article</type><title>Endoscopic Variceal Sequential Ligation Does Not Increase Risk of Gastroesophageal Reflux Disease in Cirrhosis Patients</title><source>SpringerLink Journals</source><creator>Tao, Jin ; Li, JianZhong ; Chen, XiaoLiang ; Guo, YunWei ; Tian, Hong ; Wei, XiuQing ; Zheng, FengPing ; Wen, ZhuoFu ; Wu, Bin</creator><creatorcontrib>Tao, Jin ; Li, JianZhong ; Chen, XiaoLiang ; Guo, YunWei ; Tian, Hong ; Wei, XiuQing ; Zheng, FengPing ; Wen, ZhuoFu ; Wu, Bin</creatorcontrib><description>Background
Endoscopic variceal sequential ligation (EVSL) is currently endorsed in our hospital, as the preferred endoscopic treatment for prevention of variceal rebleeding and achieving adequate hemostasis. There is currently a lack of consensus surrounding EVSL-induced changes in esophageal motor function and abnormal reflux.
Aims
To explore alterations in esophageal motor function and risk of abnormal gastroesophageal reflux in liver cirrhosis patients with esophageal varices, after EVSL.
Methods
Twenty-one liver cirrhosis patients with esophageal varices were studied using manometry and 24-h pH monitoring 1 day prior to and 1 month following EVSL. The EVSL consisted of performing esophageal variceal ligation using a multi-band ligator, which was repeated every 4 weeks until the varices were eradicated.
Results
The amplitude and duration of peristaltic contraction waves and the percentage of abnormal esophageal contraction waveforms were unaltered in both the proximal (
P
> 0.05) and the distal (
P
> 0.05) esophagus after EVSL. However, the lower esophageal sphincter pressure was decreased following EVSL (16.1 ± 7.9 mmHg
vs
21.1 ± 6.3 mmHg (
P
< 0.05)). Various quantitative parameters including percentage of total monitoring time with pH < 4.0, total number of reflux episodes, number of reflux episodes > 5 min, and DeMeester scores were not increased in post-EVSL patients. Abnormal reflux monitored by 24-h pH monitoring occurred in ten (47.6%) pre-EVSL patients and 11 (52.4%) post-EVSL patients.
Conclusions
Although EVSL affects esophageal motility by relatively decreasing LES pressure, it does not induce substantial motor abnormalities nor increase risk of abnormal gastroesophageal reflux disease in cirrhosis patients.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-019-05740-1</identifier><identifier>PMID: 31332625</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Care and treatment ; Endoscopy ; Esophagus ; Gastroenterology ; Gastroesophageal reflux ; Hepatology ; Liver ; Liver cirrhosis ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Oncology ; Original ; Original Article ; Risk factors ; Transplant Surgery</subject><ispartof>Digestive diseases and sciences, 2020-01, Vol.65 (1), p.329-335</ispartof><rights>The Author(s) 2019</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Digestive Diseases and Sciences is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-a87f61059fa832719ef0db561d5d0b13da3b89c96b10d705838099eaf8a42bbb3</citedby><cites>FETCH-LOGICAL-c541t-a87f61059fa832719ef0db561d5d0b13da3b89c96b10d705838099eaf8a42bbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-019-05740-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-019-05740-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31332625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tao, Jin</creatorcontrib><creatorcontrib>Li, JianZhong</creatorcontrib><creatorcontrib>Chen, XiaoLiang</creatorcontrib><creatorcontrib>Guo, YunWei</creatorcontrib><creatorcontrib>Tian, Hong</creatorcontrib><creatorcontrib>Wei, XiuQing</creatorcontrib><creatorcontrib>Zheng, FengPing</creatorcontrib><creatorcontrib>Wen, ZhuoFu</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><title>Endoscopic Variceal Sequential Ligation Does Not Increase Risk of Gastroesophageal Reflux Disease in Cirrhosis Patients</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
Endoscopic variceal sequential ligation (EVSL) is currently endorsed in our hospital, as the preferred endoscopic treatment for prevention of variceal rebleeding and achieving adequate hemostasis. There is currently a lack of consensus surrounding EVSL-induced changes in esophageal motor function and abnormal reflux.
Aims
To explore alterations in esophageal motor function and risk of abnormal gastroesophageal reflux in liver cirrhosis patients with esophageal varices, after EVSL.
Methods
Twenty-one liver cirrhosis patients with esophageal varices were studied using manometry and 24-h pH monitoring 1 day prior to and 1 month following EVSL. The EVSL consisted of performing esophageal variceal ligation using a multi-band ligator, which was repeated every 4 weeks until the varices were eradicated.
Results
The amplitude and duration of peristaltic contraction waves and the percentage of abnormal esophageal contraction waveforms were unaltered in both the proximal (
P
> 0.05) and the distal (
P
> 0.05) esophagus after EVSL. However, the lower esophageal sphincter pressure was decreased following EVSL (16.1 ± 7.9 mmHg
vs
21.1 ± 6.3 mmHg (
P
< 0.05)). Various quantitative parameters including percentage of total monitoring time with pH < 4.0, total number of reflux episodes, number of reflux episodes > 5 min, and DeMeester scores were not increased in post-EVSL patients. Abnormal reflux monitored by 24-h pH monitoring occurred in ten (47.6%) pre-EVSL patients and 11 (52.4%) post-EVSL patients.
Conclusions
Although EVSL affects esophageal motility by relatively decreasing LES pressure, it does not induce substantial motor abnormalities nor increase risk of abnormal gastroesophageal reflux disease in cirrhosis patients.</description><subject>Biochemistry</subject><subject>Care and treatment</subject><subject>Endoscopy</subject><subject>Esophagus</subject><subject>Gastroenterology</subject><subject>Gastroesophageal reflux</subject><subject>Hepatology</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Risk factors</subject><subject>Transplant Surgery</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kktv1DAUhS0EotOBP8ACWWLDJsXXjp14g1RNH1QaASqPreU4TsYlYw92wuPf43RKSxFCXtjy_c65ulcHoWdAjoCQ6lUCIigpCMiC8KokBTxAC-AVKygX9UO0ICDyG0AcoMOUrgghsgLxGB0wYIwKyhfo-6lvQzJh5wz-rKMzVg_4g_06WT-6_Fy7Xo8ueHwSbMJvw4gvvIlWJ4svXfqCQ4fPdRpjrobdRvez_NJ2w_QDn7h0zTmPVy7GTUgu4ffZLVunJ-hRp4dkn97cS_Tp7PTj6k2xfnd-sTpeF4aXMBa6rjoBhMtO14xWIG1H2oYLaHlLGmCtZk0tjRQNkLYivGY1kdLqrtYlbZqGLdHrve9uara2Nbl31IPaRbfV8acK2qn7Fe82qg_flJAlK4nIBi9vDGLIW0mj2rpk7DBob8OUFGWspCBmfIle_IVehSn6PJ6iVICUrOL8jur1YJXzXch9zWyqjiugkvGSz22P_kHl09qtM8HbzuX_ewK6F5gYUoq2u50RiJrjovZxUTku6jouCrLo-Z_buZX8zkcG2B5IueR7G-9G-o_tL_AxyuI</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Tao, Jin</creator><creator>Li, JianZhong</creator><creator>Chen, XiaoLiang</creator><creator>Guo, YunWei</creator><creator>Tian, Hong</creator><creator>Wei, XiuQing</creator><creator>Zheng, FengPing</creator><creator>Wen, ZhuoFu</creator><creator>Wu, Bin</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200101</creationdate><title>Endoscopic Variceal Sequential Ligation Does Not Increase Risk of Gastroesophageal Reflux Disease in Cirrhosis Patients</title><author>Tao, Jin ; Li, JianZhong ; Chen, XiaoLiang ; Guo, YunWei ; Tian, Hong ; Wei, XiuQing ; Zheng, FengPing ; Wen, ZhuoFu ; Wu, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-a87f61059fa832719ef0db561d5d0b13da3b89c96b10d705838099eaf8a42bbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biochemistry</topic><topic>Care and treatment</topic><topic>Endoscopy</topic><topic>Esophagus</topic><topic>Gastroenterology</topic><topic>Gastroesophageal reflux</topic><topic>Hepatology</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Risk factors</topic><topic>Transplant Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tao, Jin</creatorcontrib><creatorcontrib>Li, JianZhong</creatorcontrib><creatorcontrib>Chen, XiaoLiang</creatorcontrib><creatorcontrib>Guo, YunWei</creatorcontrib><creatorcontrib>Tian, Hong</creatorcontrib><creatorcontrib>Wei, XiuQing</creatorcontrib><creatorcontrib>Zheng, FengPing</creatorcontrib><creatorcontrib>Wen, ZhuoFu</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tao, Jin</au><au>Li, JianZhong</au><au>Chen, XiaoLiang</au><au>Guo, YunWei</au><au>Tian, Hong</au><au>Wei, XiuQing</au><au>Zheng, FengPing</au><au>Wen, ZhuoFu</au><au>Wu, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endoscopic Variceal Sequential Ligation Does Not Increase Risk of Gastroesophageal Reflux Disease in Cirrhosis Patients</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>65</volume><issue>1</issue><spage>329</spage><epage>335</epage><pages>329-335</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>Background
Endoscopic variceal sequential ligation (EVSL) is currently endorsed in our hospital, as the preferred endoscopic treatment for prevention of variceal rebleeding and achieving adequate hemostasis. There is currently a lack of consensus surrounding EVSL-induced changes in esophageal motor function and abnormal reflux.
Aims
To explore alterations in esophageal motor function and risk of abnormal gastroesophageal reflux in liver cirrhosis patients with esophageal varices, after EVSL.
Methods
Twenty-one liver cirrhosis patients with esophageal varices were studied using manometry and 24-h pH monitoring 1 day prior to and 1 month following EVSL. The EVSL consisted of performing esophageal variceal ligation using a multi-band ligator, which was repeated every 4 weeks until the varices were eradicated.
Results
The amplitude and duration of peristaltic contraction waves and the percentage of abnormal esophageal contraction waveforms were unaltered in both the proximal (
P
> 0.05) and the distal (
P
> 0.05) esophagus after EVSL. However, the lower esophageal sphincter pressure was decreased following EVSL (16.1 ± 7.9 mmHg
vs
21.1 ± 6.3 mmHg (
P
< 0.05)). Various quantitative parameters including percentage of total monitoring time with pH < 4.0, total number of reflux episodes, number of reflux episodes > 5 min, and DeMeester scores were not increased in post-EVSL patients. Abnormal reflux monitored by 24-h pH monitoring occurred in ten (47.6%) pre-EVSL patients and 11 (52.4%) post-EVSL patients.
Conclusions
Although EVSL affects esophageal motility by relatively decreasing LES pressure, it does not induce substantial motor abnormalities nor increase risk of abnormal gastroesophageal reflux disease in cirrhosis patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31332625</pmid><doi>10.1007/s10620-019-05740-1</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Digestive diseases and sciences, 2020-01, Vol.65 (1), p.329-335 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6943406 |
| source | SpringerLink Journals |
| subjects | Biochemistry Care and treatment Endoscopy Esophagus Gastroenterology Gastroesophageal reflux Hepatology Liver Liver cirrhosis Medical research Medicine Medicine & Public Health Medicine, Experimental Oncology Original Original Article Risk factors Transplant Surgery |
| title | Endoscopic Variceal Sequential Ligation Does Not Increase Risk of Gastroesophageal Reflux Disease in Cirrhosis Patients |
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