Inhibition of the Keap1-Nrf2 protein-protein interaction protects retinal cells and ameliorates retinal ischemia-reperfusion injury

The Nrf2-Keap1 pathway regulates transcription of a wide array of antioxidant and cytoprotective genes and offers critical protection against oxidative stress. This pathway has demonstrated benefit for a variety of retinal conditions. Retinal ischemia plays a pivotal role in many vision threatening...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Free radical biology & medicine 2020-01, Vol.146, p.181-188
Hauptverfasser:	Hui, Qiaoyan, Karlstetter, Marcus, Xu, Zhenhua, Yang, Jing, Zhou, Lingli, Eilken, Hanna M., Terjung, Carsten, Cho, Hongkwan, Gong, Junsong, Lai, Michael J., Nassar, Khaled, Duh, Elia J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Endothelial cell Endothelial Cells - metabolism Humans Inflammation Ischemia Kelch-Like ECH-Associated Protein 1 - genetics Kelch-Like ECH-Associated Protein 1 - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 Oxidative Stress Reperfusion Injury - drug therapy Reperfusion Injury - genetics Retina Retina - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!