A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer

Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical outcomes remain poor, necessitating novel therapeutic approaches. To investigate metabolic susceptibility, we performed nutrigenetic screens on a panel of clear cell and serous ovarian cancer cells and identified c...

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Veröffentlicht in:	Molecular cancer research 2020-01, Vol.18 (1), p.79-90
Hauptverfasser:	Yang, Wen-Hsuan, Huang, Zhiqing, Wu, Jianli, Ding, Chien-Kuang C, Murphy, Susan K, Chi, Jen-Tsan
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-Like Protein 4 - metabolism Carcinoma, Ovarian Epithelial - drug therapy Carcinoma, Ovarian Epithelial - metabolism Carcinoma, Ovarian Epithelial - pathology Cell Line, Tumor Cystine - deficiency Drug Resistance, Neoplasm Female Ferroptosis - physiology Humans NADPH Oxidase 2 - metabolism Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Signal Transduction Trans-Activators - metabolism Transcriptional Coactivator with PDZ-Binding Motif Proteins Transfection
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