Fundamentals of Cellular Calcium Signaling: A Primer
Ionized calcium (Ca ) is the most versatile cellular messenger. All cells use Ca signals to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular Ca signaling and/or Ca homeostasis can subvert physiological processes into driving pathological outcomes. Ima...
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| Veröffentlicht in: | Cold Spring Harbor perspectives in biology 2020-01, Vol.12 (1), p.a038802 |
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| creator | Bootman, Martin D Bultynck, Geert |
| description | Ionized calcium (Ca
) is the most versatile cellular messenger. All cells use Ca
signals to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular Ca
signaling and/or Ca
homeostasis can subvert physiological processes into driving pathological outcomes. Imaging of living cells over the past decades has demonstrated that Ca
signals encode information in their frequency, kinetics, amplitude, and spatial extent. These parameters alter depending on the type and intensity of stimulation, and cellular context. Moreover, it is evident that different cell types produce widely varying Ca
signals, with properties that suit their physiological functions. This primer discusses basic principles and mechanisms underlying cellular Ca
signaling and Ca
homeostasis. Consequently, we have cited some historical articles in addition to more recent findings. A brief summary of the core features of cellular Ca
signaling is provided, with particular focus on Ca
stores and Ca
transport across cellular membranes, as well as mechanisms by which Ca
signals activate downstream effector systems. |
| doi_str_mv | 10.1101/cshperspect.a038802 |
| format | Article |
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) is the most versatile cellular messenger. All cells use Ca
signals to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular Ca
signaling and/or Ca
homeostasis can subvert physiological processes into driving pathological outcomes. Imaging of living cells over the past decades has demonstrated that Ca
signals encode information in their frequency, kinetics, amplitude, and spatial extent. These parameters alter depending on the type and intensity of stimulation, and cellular context. Moreover, it is evident that different cell types produce widely varying Ca
signals, with properties that suit their physiological functions. This primer discusses basic principles and mechanisms underlying cellular Ca
signaling and Ca
homeostasis. Consequently, we have cited some historical articles in addition to more recent findings. A brief summary of the core features of cellular Ca
signaling is provided, with particular focus on Ca
stores and Ca
transport across cellular membranes, as well as mechanisms by which Ca
signals activate downstream effector systems.</description><identifier>ISSN: 1943-0264</identifier><identifier>EISSN: 1943-0264</identifier><identifier>DOI: 10.1101/cshperspect.a038802</identifier><identifier>PMID: 31427372</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Animals ; Binding Sites ; Calcium ; Calcium - metabolism ; Calcium Channels - metabolism ; Calcium homeostasis ; Calcium ions ; Calcium Signaling - physiology ; Calcium signalling ; Calcium transport ; Cell Membrane - metabolism ; Cell membranes ; Frequency dependence ; Homeostasis ; Humans ; Information processing ; Kinetics ; Membranes ; Oscillometry ; PERSPECTIVES ; Physiology ; Signal Transduction ; Signaling</subject><ispartof>Cold Spring Harbor perspectives in biology, 2020-01, Vol.12 (1), p.a038802</ispartof><rights>Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.</rights><rights>Copyright Cold Spring Harbor Laboratory Press Jan 2020</rights><rights>2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-b9fdf5d3e4b1d8c7341d56da0fd132e17637b8ad94e936e0dae55caf51018eac3</citedby><cites>FETCH-LOGICAL-c483t-b9fdf5d3e4b1d8c7341d56da0fd132e17637b8ad94e936e0dae55caf51018eac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942118/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942118/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31427372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bootman, Martin D</creatorcontrib><creatorcontrib>Bultynck, Geert</creatorcontrib><title>Fundamentals of Cellular Calcium Signaling: A Primer</title><title>Cold Spring Harbor perspectives in biology</title><addtitle>Cold Spring Harb Perspect Biol</addtitle><description>Ionized calcium (Ca
) is the most versatile cellular messenger. All cells use Ca
signals to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular Ca
signaling and/or Ca
homeostasis can subvert physiological processes into driving pathological outcomes. Imaging of living cells over the past decades has demonstrated that Ca
signals encode information in their frequency, kinetics, amplitude, and spatial extent. These parameters alter depending on the type and intensity of stimulation, and cellular context. Moreover, it is evident that different cell types produce widely varying Ca
signals, with properties that suit their physiological functions. This primer discusses basic principles and mechanisms underlying cellular Ca
signaling and Ca
homeostasis. Consequently, we have cited some historical articles in addition to more recent findings. A brief summary of the core features of cellular Ca
signaling is provided, with particular focus on Ca
stores and Ca
transport across cellular membranes, as well as mechanisms by which Ca
signals activate downstream effector systems.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium Channels - metabolism</subject><subject>Calcium homeostasis</subject><subject>Calcium ions</subject><subject>Calcium Signaling - physiology</subject><subject>Calcium signalling</subject><subject>Calcium transport</subject><subject>Cell Membrane - metabolism</subject><subject>Cell membranes</subject><subject>Frequency dependence</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Information processing</subject><subject>Kinetics</subject><subject>Membranes</subject><subject>Oscillometry</subject><subject>PERSPECTIVES</subject><subject>Physiology</subject><subject>Signal Transduction</subject><subject>Signaling</subject><issn>1943-0264</issn><issn>1943-0264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd1LwzAUxYMobk7_AkEKvvjSmTQfbXwQRnEqDBTU55Amt1tHP2bSCv73RjZl-nQv3N89nMNB6JzgKSGYXBu_2oDzGzD9VGOaZTg5QGMiGY1xItjh3j5CJ96vMRZCZuIYjShhSUrTZIzYfGitbqDtde2jroxyqOuh1i7KdW2qoYleqmWr66pd3kSz6NlVDbhTdFQGHM52c4Le5nev-UO8eLp_zGeL2LCM9nEhS1tyS4EVxGYmpYxYLqzGpSU0AZIKmhaZtpKBpAKw1cC50SUP6TLQhk7Q7VZ3MxQNWBNcOl2rTTCh3afqdKX-XtpqpZbdhxKSJYRkQeBqJ-C69wF8r5rKm5BQt9ANXiWUUoElIzygl__QdTe4kHxLccmxlIGiW8q4znsH5a8ZgtV3K2qvFbVrJXxd7Of4_fmpgX4BZr2MNA</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Bootman, Martin D</creator><creator>Bultynck, Geert</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200101</creationdate><title>Fundamentals of Cellular Calcium Signaling: A Primer</title><author>Bootman, Martin D ; Bultynck, Geert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-b9fdf5d3e4b1d8c7341d56da0fd132e17637b8ad94e936e0dae55caf51018eac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>Calcium Channels - metabolism</topic><topic>Calcium homeostasis</topic><topic>Calcium ions</topic><topic>Calcium Signaling - physiology</topic><topic>Calcium signalling</topic><topic>Calcium transport</topic><topic>Cell Membrane - metabolism</topic><topic>Cell membranes</topic><topic>Frequency dependence</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Information processing</topic><topic>Kinetics</topic><topic>Membranes</topic><topic>Oscillometry</topic><topic>PERSPECTIVES</topic><topic>Physiology</topic><topic>Signal Transduction</topic><topic>Signaling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bootman, Martin D</creatorcontrib><creatorcontrib>Bultynck, Geert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cold Spring Harbor perspectives in biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bootman, Martin D</au><au>Bultynck, Geert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fundamentals of Cellular Calcium Signaling: A Primer</atitle><jtitle>Cold Spring Harbor perspectives in biology</jtitle><addtitle>Cold Spring Harb Perspect Biol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>12</volume><issue>1</issue><spage>a038802</spage><pages>a038802-</pages><issn>1943-0264</issn><eissn>1943-0264</eissn><abstract>Ionized calcium (Ca
) is the most versatile cellular messenger. All cells use Ca
signals to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular Ca
signaling and/or Ca
homeostasis can subvert physiological processes into driving pathological outcomes. Imaging of living cells over the past decades has demonstrated that Ca
signals encode information in their frequency, kinetics, amplitude, and spatial extent. These parameters alter depending on the type and intensity of stimulation, and cellular context. Moreover, it is evident that different cell types produce widely varying Ca
signals, with properties that suit their physiological functions. This primer discusses basic principles and mechanisms underlying cellular Ca
signaling and Ca
homeostasis. Consequently, we have cited some historical articles in addition to more recent findings. A brief summary of the core features of cellular Ca
signaling is provided, with particular focus on Ca
stores and Ca
transport across cellular membranes, as well as mechanisms by which Ca
signals activate downstream effector systems.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>31427372</pmid><doi>10.1101/cshperspect.a038802</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Binding Sites Calcium Calcium - metabolism Calcium Channels - metabolism Calcium homeostasis Calcium ions Calcium Signaling - physiology Calcium signalling Calcium transport Cell Membrane - metabolism Cell membranes Frequency dependence Homeostasis Humans Information processing Kinetics Membranes Oscillometry PERSPECTIVES Physiology Signal Transduction Signaling |
| title | Fundamentals of Cellular Calcium Signaling: A Primer |
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