From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

The term “propagon” is used to define proteins that may transmit misfolding in vitro, in tissues or in organisms. Among propagons, misfolded tau is thought to be involved in the pathogenic mechanisms of various “tauopathies” that include Alzheimer's disease, progressive supranuclear palsy, and...

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Veröffentlicht in:	Acta neuropathologica 2020-01, Vol.139 (1), p.3-25
Hauptverfasser:	Colin, Morvane, Dujardin, Simon, Schraen-Maschke, Susanna, Meno-Tetang, Guy, Duyckaerts, Charles, Courade, Jean-Philippe, Buée, Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animal models Animals Cell culture Clinical trials Development and progression Geriatry and gerontology Health aspects Human health and pathology Humans Hypotheses Immunotherapy Immunotherapy - methods Life Sciences Medicine Medicine & Public Health Neurodegenerative diseases Neuroimaging Neurons and Cognition Neurosciences Paralysis Pathology Prions Progressive supranuclear palsy Propagation Proteostasis Deficiencies - pathology Proteostasis Deficiencies - therapy Review Tau protein Tauopathies - pathology Tauopathies - therapy Tissues and Organs
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