Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens

Morphogens are signaling molecules produced by a localized source, specifying cell fate in a graded manner. The source secretes morphogens into the extracellular milieu to activate various target genes in an autocrine or paracrine manner. Here we describe various secreted forms of two canonical morp...

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Veröffentlicht in:	Trends in cell biology 2018-02, Vol.28 (2), p.157-170
Hauptverfasser:	Parchure, Anup, Vyas, Neha, Mayor, Satyajit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autocrine signalling cancer Cell fate Drosophila Proteins - metabolism exosomes Extracellular matrix Hedgehog protein Hedgehog Proteins - metabolism Humans Lipid Metabolism - physiology lipoprotein Molecular chains Morphogenesis Morphogenesis - physiology Paracrine signalling Secretion Signaling Studies tissue patterning vesicles Wnt Wnt protein Wnt Proteins - metabolism
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