Exploiting CD22 To Selectively Tolerize Autoantibody Producing B‑Cells in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease that primarily affects the synovial joints and can lead to bone erosion and cartilage damage. One hallmark of RA is anticitrullinated protein autoantibodies (ACPA) and memory citrulline-specific B-cells, which have been implicated in RA pathogenesis...

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Veröffentlicht in:	ACS chemical biology 2019-04, Vol.14 (4), p.644-654
Hauptverfasser:	Bednar, Kyle J, Nycholat, Corwin M, Rao, Tadimeti S, Paulson, James C, Fung-Leung, Wai-Ping, Macauley, Matthew S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Rheumatoid - metabolism Autoantibodies - immunology B-Lymphocytes - immunology Case-Control Studies Citrulline - metabolism Humans Immunologic Memory Mice Sialic Acid Binding Ig-like Lectin 2 - metabolism
Online-Zugang:	Volltext
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