Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and...
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| Veröffentlicht in: | Nature reviews. Microbiology 2019-04, Vol.17 (4), p.203-218 |
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| creator | Turner, Nicholas A. Sharma-Kuinkel, Batu K. Maskarinec, Stacey A. Eichenberger, Emily M. Shah, Pratik P. Carugati, Manuela Holland, Thomas L. Fowler, Vance G. |
| description | Methicillin-resistant
Staphylococcus aureus
(MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.
Methicillin-resistant
Staphylococcus aureus
(MRSA) is a major pathogen both within hospitals and in the community. In this Review, Fowler and colleagues provide an overview of basic and clinical MRSA research and explore the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA. |
| doi_str_mv | 10.1038/s41579-018-0147-4 |
| format | Article |
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Staphylococcus aureus
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Methicillin-resistant
Staphylococcus aureus
(MRSA) is a major pathogen both within hospitals and in the community. In this Review, Fowler and colleagues provide an overview of basic and clinical MRSA research and explore the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.</description><identifier>ISSN: 1740-1526</identifier><identifier>EISSN: 1740-1534</identifier><identifier>DOI: 10.1038/s41579-018-0147-4</identifier><identifier>PMID: 30737488</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326/107 ; 631/326/22/1434 ; 631/326/2521 ; 631/326/41 ; 631/326/421 ; Anti-Bacterial Agents - pharmacology ; Antimicrobial agents ; Bacteremia ; Bacteremia - epidemiology ; Biodiversity ; Biological evolution ; Biomedical and Life Sciences ; Care and treatment ; Ceftaroline ; Clinical trials ; Clinical Trials as Topic ; Communicable diseases ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - microbiology ; Consultation ; Cross infection ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Dalbavancin ; Development and progression ; Disease control ; Disease transmission ; Drug resistance ; Echocardiography ; Endocarditis ; Epidemics ; Epidemiology ; Evolution ; Evolution, Molecular ; Genetic aspects ; Genetic diversity ; Genetic research ; Genetic Variation ; Genotypes ; Health aspects ; Health services ; Hospitals ; Humans ; Identification and classification ; Incidence ; Infection ; Infectious Diseases ; Life Sciences ; Medical Microbiology ; Medical research ; Methicillin ; Methicillin - pharmacology ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - pathogenicity ; Microbial drug resistance ; Microbiology ; Morbidity ; Mupirocin ; Nosocomial infection ; Nosocomial infections ; Parasitology ; Pathogenic microorganisms ; Pathogens ; Public health ; Review Article ; Skin ; Soft Tissue Infections - epidemiology ; Soft Tissue Infections - microbiology ; Soft tissues ; Staphylococcal infections ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - epidemiology ; Staphylococcus aureus ; Staphylococcus aureus infections ; Staphylococcus infections ; Surveillance ; Tetracyclines ; Virology</subject><ispartof>Nature reviews. Microbiology, 2019-04, Vol.17 (4), p.203-218</ispartof><rights>Springer Nature Limited 2019</rights><rights>COPYRIGHT 2019 Nature Publishing Group</rights><rights>2019© Springer Nature Limited 2019</rights><rights>Copyright Nature Publishing Group Apr 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c679t-10069c0df2aad8589afd420551e6c171cee0ffad88ecfcb11b2dedbf38c244313</citedby><cites>FETCH-LOGICAL-c679t-10069c0df2aad8589afd420551e6c171cee0ffad88ecfcb11b2dedbf38c244313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41579-018-0147-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41579-018-0147-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30737488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turner, Nicholas A.</creatorcontrib><creatorcontrib>Sharma-Kuinkel, Batu K.</creatorcontrib><creatorcontrib>Maskarinec, Stacey A.</creatorcontrib><creatorcontrib>Eichenberger, Emily M.</creatorcontrib><creatorcontrib>Shah, Pratik P.</creatorcontrib><creatorcontrib>Carugati, Manuela</creatorcontrib><creatorcontrib>Holland, Thomas L.</creatorcontrib><creatorcontrib>Fowler, Vance G.</creatorcontrib><title>Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research</title><title>Nature reviews. Microbiology</title><addtitle>Nat Rev Microbiol</addtitle><addtitle>Nat Rev Microbiol</addtitle><description>Methicillin-resistant
Staphylococcus aureus
(MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.
Methicillin-resistant
Staphylococcus aureus
(MRSA) is a major pathogen both within hospitals and in the community. In this Review, Fowler and colleagues provide an overview of basic and clinical MRSA research and explore the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.</description><subject>631/326/107</subject><subject>631/326/22/1434</subject><subject>631/326/2521</subject><subject>631/326/41</subject><subject>631/326/421</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial agents</subject><subject>Bacteremia</subject><subject>Bacteremia - epidemiology</subject><subject>Biodiversity</subject><subject>Biological evolution</subject><subject>Biomedical and Life Sciences</subject><subject>Care and treatment</subject><subject>Ceftaroline</subject><subject>Clinical trials</subject><subject>Clinical Trials as Topic</subject><subject>Communicable diseases</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Community-Acquired Infections - microbiology</subject><subject>Consultation</subject><subject>Cross infection</subject><subject>Cross Infection - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature reviews. Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turner, Nicholas A.</au><au>Sharma-Kuinkel, Batu K.</au><au>Maskarinec, Stacey A.</au><au>Eichenberger, Emily M.</au><au>Shah, Pratik P.</au><au>Carugati, Manuela</au><au>Holland, Thomas L.</au><au>Fowler, Vance G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research</atitle><jtitle>Nature reviews. Microbiology</jtitle><stitle>Nat Rev Microbiol</stitle><addtitle>Nat Rev Microbiol</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>17</volume><issue>4</issue><spage>203</spage><epage>218</epage><pages>203-218</pages><issn>1740-1526</issn><eissn>1740-1534</eissn><abstract>Methicillin-resistant
Staphylococcus aureus
(MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.
Methicillin-resistant
Staphylococcus aureus
(MRSA) is a major pathogen both within hospitals and in the community. In this Review, Fowler and colleagues provide an overview of basic and clinical MRSA research and explore the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30737488</pmid><doi>10.1038/s41579-018-0147-4</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1740-1526 |
| ispartof | Nature reviews. Microbiology, 2019-04, Vol.17 (4), p.203-218 |
| issn | 1740-1526 1740-1534 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6939889 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | 631/326/107 631/326/22/1434 631/326/2521 631/326/41 631/326/421 Anti-Bacterial Agents - pharmacology Antimicrobial agents Bacteremia Bacteremia - epidemiology Biodiversity Biological evolution Biomedical and Life Sciences Care and treatment Ceftaroline Clinical trials Clinical Trials as Topic Communicable diseases Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Consultation Cross infection Cross Infection - epidemiology Cross Infection - microbiology Dalbavancin Development and progression Disease control Disease transmission Drug resistance Echocardiography Endocarditis Epidemics Epidemiology Evolution Evolution, Molecular Genetic aspects Genetic diversity Genetic research Genetic Variation Genotypes Health aspects Health services Hospitals Humans Identification and classification Incidence Infection Infectious Diseases Life Sciences Medical Microbiology Medical research Methicillin Methicillin - pharmacology Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - pathogenicity Microbial drug resistance Microbiology Morbidity Mupirocin Nosocomial infection Nosocomial infections Parasitology Pathogenic microorganisms Pathogens Public health Review Article Skin Soft Tissue Infections - epidemiology Soft Tissue Infections - microbiology Soft tissues Staphylococcal infections Staphylococcal Infections - drug therapy Staphylococcal Infections - epidemiology Staphylococcus aureus Staphylococcus aureus infections Staphylococcus infections Surveillance Tetracyclines Virology |
| title | Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T21%3A05%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Methicillin-resistant%20Staphylococcus%20aureus:%20an%20overview%20of%20basic%20and%20clinical%20research&rft.jtitle=Nature%20reviews.%20Microbiology&rft.au=Turner,%20Nicholas%20A.&rft.date=2019-04-01&rft.volume=17&rft.issue=4&rft.spage=203&rft.epage=218&rft.pages=203-218&rft.issn=1740-1526&rft.eissn=1740-1534&rft_id=info:doi/10.1038/s41579-018-0147-4&rft_dat=%3Cgale_pubme%3EA578489221%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2191351250&rft_id=info:pmid/30737488&rft_galeid=A578489221&rfr_iscdi=true |