Immune mechanisms of oral immunotherapy
Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.491-498 |
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| container_end_page | 498 |
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| container_issue | 2 |
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| container_title | Journal of allergy and clinical immunology |
| container_volume | 141 |
| creator | Kulis, Michael D. Patil, Sarita U. Wambre, Erik Vickery, Brian P. |
| description | Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms of action is lacking. In this rostrum we review the current evidence regarding the human immune response to OIT, explore possible mechanisms, and identify knowledge gaps for future research. |
| doi_str_mv | 10.1016/j.jaci.2017.12.979 |
| format | Article |
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These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms of action is lacking. In this rostrum we review the current evidence regarding the human immune response to OIT, explore possible mechanisms, and identify knowledge gaps for future research.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2017.12.979</identifier><identifier>PMID: 29288078</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Oral ; Allergens ; Allergens - immunology ; Allergens - therapeutic use ; antibodies ; Antigens ; B cells ; basophils ; Clinical trials ; Desensitization ; Desensitization (Psychology) ; Desensitization, Immunologic - methods ; Food allergies ; Food Hypersensitivity - immunology ; Food Hypersensitivity - pathology ; Food Hypersensitivity - therapy ; Human behavior ; Humans ; immune mechanisms ; Immune response ; Immunoglobulins ; Immunotherapy ; mast cells ; Oral immunotherapy ; Rostrum ; sustained unresponsiveness ; T cells</subject><ispartof>Journal of allergy and clinical immunology, 2018-02, Vol.141 (2), p.491-498</ispartof><rights>2017 American Academy of Allergy, Asthma & Immunology</rights><rights>Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. 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These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms of action is lacking. In this rostrum we review the current evidence regarding the human immune response to OIT, explore possible mechanisms, and identify knowledge gaps for future research.</description><subject>Administration, Oral</subject><subject>Allergens</subject><subject>Allergens - immunology</subject><subject>Allergens - therapeutic use</subject><subject>antibodies</subject><subject>Antigens</subject><subject>B cells</subject><subject>basophils</subject><subject>Clinical trials</subject><subject>Desensitization</subject><subject>Desensitization (Psychology)</subject><subject>Desensitization, Immunologic - methods</subject><subject>Food allergies</subject><subject>Food Hypersensitivity - immunology</subject><subject>Food Hypersensitivity - pathology</subject><subject>Food Hypersensitivity - therapy</subject><subject>Human behavior</subject><subject>Humans</subject><subject>immune mechanisms</subject><subject>Immune response</subject><subject>Immunoglobulins</subject><subject>Immunotherapy</subject><subject>mast cells</subject><subject>Oral immunotherapy</subject><subject>Rostrum</subject><subject>sustained unresponsiveness</subject><subject>T cells</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtLAzEUhYMoWh9_wIUUXOimY24ykweIIMUXFNzoOmTSjM3QmdRkpuC_N0OrqAtX4XK_c3LvPQidAs4AA7uqs1oblxEMPAOSSS530Aiw5BMmSLGLRhhLmDCeywN0GGONU02F3EcHRBIhMBcjdPHUNH1rx401C9262MSxr8Y-6OXYDR3fLWzQq49jtFfpZbQn2_cIvd7fvUwfJ7Pnh6fp7WxickG79BmvKMdQFbpkmpOcFlJXROYYpGGyxJUGY0vgFIATMLRkuJxrXbCiAM4LeoRuNr6rvmzs3Ni2S7OoVXCNDh_Ka6d-d1q3UG9-rZikUhQiGVxuDYJ_723sVOOisculbq3vowIpiMiB5jKh53_Q2vehTeupdNOcMk5zliiyoUzwMQZbfQ8DWA05qFoNOQwaroColEMSnf1c41vydfgEXG8Am465djaoaJxtjZ27YE2n5t795_8JRXCYHw</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Kulis, Michael D.</creator><creator>Patil, Sarita U.</creator><creator>Wambre, Erik</creator><creator>Vickery, Brian P.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180201</creationdate><title>Immune mechanisms of oral immunotherapy</title><author>Kulis, Michael D. ; Patil, Sarita U. ; Wambre, Erik ; Vickery, Brian P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-677f3701f5ab6a724359af294019c69b0fa1ceb17311721c3b60bdaa565517753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Administration, Oral</topic><topic>Allergens</topic><topic>Allergens - immunology</topic><topic>Allergens - therapeutic use</topic><topic>antibodies</topic><topic>Antigens</topic><topic>B cells</topic><topic>basophils</topic><topic>Clinical trials</topic><topic>Desensitization</topic><topic>Desensitization (Psychology)</topic><topic>Desensitization, Immunologic - methods</topic><topic>Food allergies</topic><topic>Food Hypersensitivity - immunology</topic><topic>Food Hypersensitivity - pathology</topic><topic>Food Hypersensitivity - therapy</topic><topic>Human behavior</topic><topic>Humans</topic><topic>immune mechanisms</topic><topic>Immune response</topic><topic>Immunoglobulins</topic><topic>Immunotherapy</topic><topic>mast cells</topic><topic>Oral immunotherapy</topic><topic>Rostrum</topic><topic>sustained unresponsiveness</topic><topic>T cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulis, Michael D.</creatorcontrib><creatorcontrib>Patil, Sarita U.</creatorcontrib><creatorcontrib>Wambre, Erik</creatorcontrib><creatorcontrib>Vickery, Brian P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulis, Michael D.</au><au>Patil, Sarita U.</au><au>Wambre, Erik</au><au>Vickery, Brian P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune mechanisms of oral immunotherapy</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>141</volume><issue>2</issue><spage>491</spage><epage>498</epage><pages>491-498</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. 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| ispartof | Journal of allergy and clinical immunology, 2018-02, Vol.141 (2), p.491-498 |
| issn | 0091-6749 1097-6825 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Administration, Oral Allergens Allergens - immunology Allergens - therapeutic use antibodies Antigens B cells basophils Clinical trials Desensitization Desensitization (Psychology) Desensitization, Immunologic - methods Food allergies Food Hypersensitivity - immunology Food Hypersensitivity - pathology Food Hypersensitivity - therapy Human behavior Humans immune mechanisms Immune response Immunoglobulins Immunotherapy mast cells Oral immunotherapy Rostrum sustained unresponsiveness T cells |
| title | Immune mechanisms of oral immunotherapy |
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