Characterization of a novel glycosylated glutathione transferase of Onchocerca ochengi , closest relative of the human river blindness parasite

Filarial nematodes possess glutathione transferases (GSTs), ubiquitous enzymes with the potential to detoxify xenobiotic and endogenous substrates, and modulate the host immune system, which may aid worm infection establishment, maintenance and survival in the host. Here we have identified and chara...

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Veröffentlicht in:	Parasitology 2019-12, Vol.146 (14), p.1773-1784
Hauptverfasser:	Rose, Clair, Praulins, Giorgio, Armstrong, Stuart D, Casas-Sanchez, Aitor, Davis, Jem, Molyneux, Gemma, Yunta, Cristina, Stead, Zenaida, Prescott, Mark, Perally, Samirah, Rutter, Anne, Makepeace, Benjamin L, La Course, E James, Acosta-Serrano, Alvaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity chromatography Amino acids Blindness Chromatography Deglycosylation enzyme activity Enzymes Females Gel electrophoresis Glutathione Glutathione transferase glycosylation Homogenization Homology Host-parasite interactions host-parasite relationships human diseases humans Immune system Liquid chromatography Mass spectrometry Mass spectroscopy N-glycans Nematodes Onchocerca ochengi Onchocerca volvulus Onchocerciasis Parasites Peptides polyacrylamide gel electrophoresis Polysaccharides Potassium Prostaglandin synthase Proteins Rivers Sodium lauryl sulfate Substrates Tropical diseases Vaccines Water analysis Worms xenobiotics
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