Notch3 promotes prostate cancer-induced bone lesion development via MMP-3

Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with high-grade disease and metastasis. To address how Notch affects prostate cancer bone lesions, we manipulated Notch expression in mouse tibia xenograf...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2020-01, Vol.39 (1), p.204-218
Hauptverfasser:	Ganguly, Sourik S., Hostetter, Galen, Tang, Lin, Frank, Sander B., Saboda, Kathylynn, Mehra, Rohit, Wang, Lisha, Li, Xiaohong, Keller, Evan T., Miranti, Cindy K.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/105 13/21 13/51 13/89 38/77 631/67/322 631/80 64 64/60 82 82/1 82/80 Animals Apoptosis B cells Bone cancer Bone lesions Bone Neoplasms - genetics Bone Neoplasms - pathology Bone Neoplasms - secondary Cell Biology Cell differentiation Cell Differentiation - genetics Cell Line, Tumor Cell proliferation Gene Expression Regulation, Neoplastic - genetics Heterografts Human Genetics Humans Internal Medicine Male Matrix Metalloproteinase 3 - genetics Medicine Medicine & Public Health Metastases Metastasis Mice Neoplasm Metastasis Oncology Osteoblastogenesis Osteoblasts Osteoblasts - metabolism Osteoblasts - pathology Osteoclastogenesis Osteoclasts Osteoclasts - metabolism Osteoclasts - pathology Osteogenesis - genetics Osteolysis Phenotypes Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Receptor, Notch3 - genetics Signal Transduction - genetics Tibia Tumor cell lines Tumor cells Tumor microenvironment Tumors Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!