Nafamostat and sepimostat identified as novel neuroprotective agents via NR2B N-methyl-D-aspartate receptor antagonism using a rat retinal excitotoxicity model

In addition to its role in the treatment of pancreatitis, the serine protease inhibitor nafamostat exhibits a retinal protective effect. However, the exact mechanisms underlying this effect are unknown. In this study, the neuroprotective effects of nafamostat and its orally active derivative sepimos...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.20409-12, Article 20409
Hauptverfasser:	Fuwa, Masahiro, Kageyama, Masaaki, Ohashi, Koji, Sasaoka, Masaaki, Sato, Ryuichi, Tanaka, Masami, Tashiro, Kei
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436/2387 631/378 692/308/153 692/617/375/364 692/699/3161 Animals Binding sites Cell death Cell Death - drug effects Cerebral Cortex - drug effects Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Excitotoxicity Glutamic acid receptors (ionotropic) Guanidines - pharmacology Guanidines - therapeutic use Humanities and Social Sciences Imidazoles - pharmacology Imidazoles - therapeutic use multidisciplinary N-Methyl-D-aspartic acid receptors Neurodegeneration Neurons - drug effects Neuroprotection Neuroprotective agents Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Pancreatitis Proteinase inhibitors Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Retina Retinal degeneration Retinal Degeneration - prevention & control Science Science (multidisciplinary) Serine Serine proteinase Spermidine
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