Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome

Acute respiratory distress syndrome (ARDS) lacks known causal biomarkers. Plasma concentrations of sRAGE (soluble receptor for advanced glycation end products) strongly associate with ARDS risk. However, whether plasma sRAGE contributes causally to ARDS remains unknown. Evaluate plasma sRAGE as a ca...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2020-01, Vol.201 (1), p.47-56
Hauptverfasser:	Jones, Tiffanie K, Feng, Rui, Kerchberger, V Eric, Reilly, John P, Anderson, Brian J, Shashaty, Michael G S, Wang, Fan, Dunn, Thomas G, Riley, Thomas R, Abbott, Jason, Ittner, Caroline A G, Christiani, David C, Mikacenic, Carmen, Wurfel, Mark M, Ware, Lorraine B, Calfee, Carolyn S, Matthay, Michael A, Christie, Jason D, Meyer, Nuala J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers - blood Black People - genetics Cohort Studies Critical care Critical Illness Female Humans Lung diseases Male Middle Aged Original Plasma Receptor for Advanced Glycation End Products - genetics Respiratory Distress Syndrome - blood Respiratory Distress Syndrome - physiopathology Risk Factors Sepsis Sepsis - blood Sepsis - genetics Sepsis - physiopathology White People - genetics
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