Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2

B-cell adaptor protein (BCAP) is a multimodular, multifunctional signal transducer that regulates signal transduction pathways in leukocytes, including macrophages, B-cells, and T-cells. In particular, BCAP suppresses inflammatory signaling by Toll-like receptors (TLRs). However, how BCAP itself is...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2019-12, Vol.294 (52), p.19852-19861
Hauptverfasser:	Lauenstein, Johannes U., Udgata, Atul, Bartram, Alex, De Sutter, Delphine, Fisher, David I., Halabi, Samer, Eyckerman, Sven, Gay, Nicholas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Agammaglobulinaemia Tyrosine Kinase - metabolism Amino Acid Motifs B-cell adaptor protein Binding Sites Cell Line, Tumor Genes, Reporter GRB2 Adaptor Protein - metabolism HEK293 Cells Humans immunity Immunology kinase signaling Mass Spectrometry Oncogene Proteins - metabolism Peptides - analysis Phosphatidylinositol 3-Kinases - metabolism phosphoinositide 3-kinase Phosphorylation Protein Binding signal transduction Src homology 2 domain (SH2 domain) Src homology 3 domain (SH3 domain) src Homology Domains Toll-like receptor (TLR) virotrap
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!