Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro

The HECT E3 ligase family comprises three subfamilies: NEDD4 E3 ubiquitin protein ligase (NEDD4), HECT and RLD domain–containing E3 ubiquitin protein ligase (HERC), and “other.” Most previous studies have focused on the NEDD4 subfamily. Apoptosis-resistant E3 ligase 1 (AREL1) belongs to “other” subf...

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Veröffentlicht in:	The Journal of biological chemistry 2019-12, Vol.294 (52), p.19934-19949
Hauptverfasser:	Singh, Sunil, Ng, Joel, Nayak, Digant, Sivaraman, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis Apoptosis Regulatory Proteins - chemistry Apoptosis Regulatory Proteins - metabolism apoptosis-resistant E3 ligase 1 (AREL1) autopolyubiquitination BASIC BIOLOGICAL SCIENCES cancer cancer apoptosis-resistant E3 ligase 1 (AREL1) crystal structure Crystallography, X-Ray E3 ubiquitin ligase HECT domain Humans INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Mitochondrial Proteins - chemistry Mitochondrial Proteins - metabolism Molecular Dynamics Simulation Mutagenesis, Site-Directed Nedd4 Ubiquitin Protein Ligases - chemistry Nedd4 Ubiquitin Protein Ligases - genetics Nedd4 Ubiquitin Protein Ligases - metabolism post-translational modification (PTM) protein degradation Protein Domains Protein Structure, Quaternary Protein Structure, Tertiary Protein Synthesis and Degradation Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification second mitochondria-derived activator of caspase (SMAC) structural biology structure-function Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination ubiquitylation (ubiquitination)
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