The sensor kinase MtrB of Mycobacterium tuberculosis regulates hypoxic survival and establishment of infection

Paired two-component systems (TCSs), having a sensor kinase (SK) and a cognate response regulator (RR), enable the human pathogen Mycobacterium tuberculosis to respond to the external environment and to persist within its host. Here, we inactivated the SK gene of the TCS MtrAB, mtrB, generating the...

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Veröffentlicht in:	The Journal of biological chemistry 2019-12, Vol.294 (52), p.19862-19876
Hauptverfasser:	Banerjee, Srijon Kaushik, Lata, Suruchi, Sharma, Arun Kumar, Bagchi, Shreya, Kumar, Manish, Sahu, Sanjaya Kumar, Sarkar, Debasree, Gupta, Pushpa, Jana, Kuladip, Gupta, Umesh Datta, Singh, Ramandeep, Saha, Sudipto, Basu, Joyoti, Kundu, Manikuntala
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Autophagosomes - metabolism bacterial persistence Bacterial Proteins - genetics Bacterial Proteins - metabolism bacterial signal transduction bacterial survival biofilm Biofilms - growth & development Cytokines - metabolism DNA-Binding Proteins - metabolism dormancy Gene Regulatory Networks Host-Pathogen Interactions Humans hypoxia infection Lung Diseases - microbiology Lung Diseases - pathology Lung Diseases - veterinary Lysosomes - metabolism Macrophages - cytology Macrophages - immunology Macrophages - microbiology Mice Mice, Inbred BALB C Microbiology MtrB Mycobacterium tuberculosis Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - physiology Phosphorylation Promoter Regions, Genetic Protein Binding RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism sensor kinase Transcription Factors - genetics Transcription Factors - metabolism two component system virulence
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