Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas

Osteosarcoma (OS) patients with metastasis or recurrent tumors still suffer from poor prognosis. Studies have indicated the efficacy of DNA demethylation therapy for OS, but the underlying mechanism is still unclear. Here, we aimed to clarify the mechanism of how epigenetic therapy has therapeutic e...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.20360-11, Article 20360
Hauptverfasser:	Asano, Naofumi, Takeshima, Hideyuki, Yamashita, Satoshi, Takamatsu, Hironori, Hattori, Naoko, Kubo, Takashi, Yoshida, Akihiko, Kobayashi, Eisuke, Nakayama, Robert, Matsumoto, Morio, Nakamura, Masaya, Ichikawa, Hitoshi, Kawai, Akira, Kondo, Tadashi, Ushijima, Toshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	13/105 38/39 38/61 631/67/1059/99 64/60 692/4028/67/1344 692/4028/67/1798 692/4028/67/2332 Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Azacytidine Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell activation Cell proliferation Cellular Reprogramming - drug effects Cellular Reprogramming - genetics Chondrogenesis CpG islands Demethylation Deoxyribonucleic acid DNA DNA methylation DNA Methylation - drug effects DNA microarrays Epigenesis, Genetic - drug effects Epigenetics Ewing's sarcoma Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Gene silencing Genome-Wide Association Study Genomes Humanities and Social Sciences Humans Metastases Morphogenesis multidisciplinary Osteogenesis Osteogenesis - genetics Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Sarcoma Science Science (multidisciplinary) Skeletal system Transcription activation Tumors Xenografts
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