Mitochondrial dysfunction is associated with Miro1 reduction in lung epithelial cells by cigarette smoke

[Display omitted] •Cigarette smoke extract (CSE) treatment induces mitochondrial dyfunction.•CSE alters OXPHOS and mitochondrial respiration.•CSE causes perinuclear mitochondrial clustering and fragmentation.•Miro1 reduction by CSE affects mitochondrial trafficking and mitophagy. Cigarette smoke (CS...

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Veröffentlicht in:	Toxicology letters 2019-12, Vol.317, p.92-101
Hauptverfasser:	Sundar, Isaac K., Maremanda, Krishna P., Rahman, Irfan
Format:	Artikel
Sprache:	eng
Schlagworte:	Case-Control Studies Cells, Cultured Cigarette smoke Cigarette Smoking - adverse effects Down-Regulation Energy Metabolism Epithelial cells Epithelial Cells - metabolism Epithelial Cells - ultrastructure Humans Lung - metabolism Lung - ultrastructure Miro1 Mitochondria - metabolism Mitochondria - ultrastructure Mitochondrial dysfunction Mitochondrial Proteins - metabolism Mitophagy Oxidative Stress Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology rho GTP-Binding Proteins - metabolism Signal Transduction Smoke - adverse effects
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