Additive Therapeutic Effects of Mesenchymal Stem Cells and IL-37 for Systemic Lupus Erythematosus

Although mesenchymal stem cells (MSCs) might offer a promising strategy for treating SLE, their immunoregulatory plasticity makes their therapeutic effects unpredictable. Whether overexpressing IL-37, an IL-1 family member with immunosuppressive activity, might enhance the therapeutic effects of the...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2020-01, Vol.31 (1), p.54-65
Hauptverfasser:	Xu, Jianyong, Chen, Jieting, Li, Wenlei, Lian, Wei, Huang, Jieyong, Lai, Baoyu, Li, Lingyun, Huang, Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Research Cells, Cultured Combined Modality Therapy Female Interleukin-1 - biosynthesis Interleukin-1 - therapeutic use Lupus Erythematosus, Systemic - therapy Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells - metabolism Mice Mice, Inbred MRL lpr
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