Association between skeletal muscle attenuation and gastroesophageal reflux disease: A health check-up cohort study
Sarcopenia is defined as skeletal muscle attenuation and has an association with metabolic syndrome. Metabolic syndrome, which includes obesity, is one of known predictive factors for gastroesophageal reflux disease (GERD). This study aimed to elucidate the association between sarcopenia and GERD. W...
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| Veröffentlicht in: | Scientific reports 2019-12, Vol.9 (1), p.20102-8, Article 20102 |
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| description | Sarcopenia is defined as skeletal muscle attenuation and has an association with metabolic syndrome. Metabolic syndrome, which includes obesity, is one of known predictive factors for gastroesophageal reflux disease (GERD). This study aimed to elucidate the association between sarcopenia and GERD. We retrospectively reviewed electronic medical records of 8,218 patients who were performed an upper gastrointestinal endoscopy at check-up center of the Gangnam Severance Hospital. GERD was diagnosed by endoscopic findings. Erosive reflux disease (ERD) included Barrett's esophagus and reflux esophagitis, with the exception of minimal change esophagitis. Sarcopenia was defined by appendicular skeletal muscle (skeletal muscle in the upper and lower limbs). Sarcopenic obesity was defined as the presence of both sarcopenia and obesity. Associations between sarcopenia and GERD, as well as between sarcopenic obesity and ERD, were analyzed. A total of 3,414 patients were diagnosed with GERD, and 574 (16.8%) had sarcopenia. Sarcopenia was independent predictive factor for GERD (odds ratio [OR] = 1.170, 95% confidence interval [CI]: 1.016–1.346,
P
= 0.029). In addition, male sex, smoking, alcohol, and diet, including sweets and fatty food, had a significant association with GERD. A total of 1,423 (17.3%) of 8,218 patients were diagnosed with ERD, and 302 (21.2%) had sarcopenia. Male sex, smoking, and fatty food consumption had a significant association with ERD. Moreover, sarcopenia (OR = 1.215, 95% CI: 1.019–1.449,
P
= 0.030), obesity (OR = 1.343, 95% CI: 1.163–1.552,
P
|
| doi_str_mv | 10.1038/s41598-019-56702-6 |
| format | Article |
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P
= 0.029). In addition, male sex, smoking, alcohol, and diet, including sweets and fatty food, had a significant association with GERD. A total of 1,423 (17.3%) of 8,218 patients were diagnosed with ERD, and 302 (21.2%) had sarcopenia. Male sex, smoking, and fatty food consumption had a significant association with ERD. Moreover, sarcopenia (OR = 1.215, 95% CI: 1.019–1.449,
P
= 0.030), obesity (OR = 1.343, 95% CI: 1.163–1.552,
P
< 0.001), and sarcopenic obesity (OR = 1.406, 95% CI: 1.195–1.654,
P
< 0.001) were independent predictive factors for ERD. Sarcopenia is associated with GERD, and sarcopenic obesity may be predictive factor for ERD.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-56702-6</identifier><identifier>PMID: 31882910</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/4020/1503/2753/196 ; 692/4020/2741/1479 ; Adult ; Anthropometry ; Barrett's esophagus ; Biomarkers ; Cohort analysis ; Cohort Studies ; Cross-Sectional Studies ; Disease Susceptibility ; Electronic medical records ; Endoscopy ; Esophagitis ; Female ; Food consumption ; Gastroesophageal reflux ; Gastroesophageal Reflux - epidemiology ; Gastroesophageal Reflux - etiology ; Gastroesophageal Reflux - physiopathology ; Humanities and Social Sciences ; Humans ; Male ; Metabolic disorders ; Metabolic syndrome ; Middle Aged ; multidisciplinary ; Muscle, Skeletal - physiopathology ; Musculoskeletal system ; Obesity ; Patients ; Republic of Korea - epidemiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sarcopenia ; Science ; Science (multidisciplinary) ; Skeletal muscle ; Smoking</subject><ispartof>Scientific reports, 2019-12, Vol.9 (1), p.20102-8, Article 20102</ispartof><rights>The Author(s) 2019</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-90800229e355c293f7940837b054ac42be6b2436246c0bf7d6a077741cd6e5f03</citedby><cites>FETCH-LOGICAL-c474t-90800229e355c293f7940837b054ac42be6b2436246c0bf7d6a077741cd6e5f03</cites><orcidid>0000-0002-3790-7701 ; 0000-0002-9198-3326</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934459/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934459/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31882910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Young Min</creatorcontrib><creatorcontrib>Kim, Jie-Hyun</creatorcontrib><creatorcontrib>Baik, Su Jung</creatorcontrib><creatorcontrib>Jung, Da Hyun</creatorcontrib><creatorcontrib>Park, Jae Jun</creatorcontrib><creatorcontrib>Youn, Young Hoon</creatorcontrib><creatorcontrib>Park, Hyojin</creatorcontrib><title>Association between skeletal muscle attenuation and gastroesophageal reflux disease: A health check-up cohort study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Sarcopenia is defined as skeletal muscle attenuation and has an association with metabolic syndrome. Metabolic syndrome, which includes obesity, is one of known predictive factors for gastroesophageal reflux disease (GERD). This study aimed to elucidate the association between sarcopenia and GERD. We retrospectively reviewed electronic medical records of 8,218 patients who were performed an upper gastrointestinal endoscopy at check-up center of the Gangnam Severance Hospital. GERD was diagnosed by endoscopic findings. Erosive reflux disease (ERD) included Barrett's esophagus and reflux esophagitis, with the exception of minimal change esophagitis. Sarcopenia was defined by appendicular skeletal muscle (skeletal muscle in the upper and lower limbs). Sarcopenic obesity was defined as the presence of both sarcopenia and obesity. Associations between sarcopenia and GERD, as well as between sarcopenic obesity and ERD, were analyzed. A total of 3,414 patients were diagnosed with GERD, and 574 (16.8%) had sarcopenia. Sarcopenia was independent predictive factor for GERD (odds ratio [OR] = 1.170, 95% confidence interval [CI]: 1.016–1.346,
P
= 0.029). In addition, male sex, smoking, alcohol, and diet, including sweets and fatty food, had a significant association with GERD. A total of 1,423 (17.3%) of 8,218 patients were diagnosed with ERD, and 302 (21.2%) had sarcopenia. Male sex, smoking, and fatty food consumption had a significant association with ERD. Moreover, sarcopenia (OR = 1.215, 95% CI: 1.019–1.449,
P
= 0.030), obesity (OR = 1.343, 95% CI: 1.163–1.552,
P
< 0.001), and sarcopenic obesity (OR = 1.406, 95% CI: 1.195–1.654,
P
< 0.001) were independent predictive factors for ERD. Sarcopenia is associated with GERD, and sarcopenic obesity may be predictive factor for ERD.</description><subject>692/4020/1503/2753/196</subject><subject>692/4020/2741/1479</subject><subject>Adult</subject><subject>Anthropometry</subject><subject>Barrett's esophagus</subject><subject>Biomarkers</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Disease Susceptibility</subject><subject>Electronic medical records</subject><subject>Endoscopy</subject><subject>Esophagitis</subject><subject>Female</subject><subject>Food consumption</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - epidemiology</subject><subject>Gastroesophageal Reflux - etiology</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Musculoskeletal system</subject><subject>Obesity</subject><subject>Patients</subject><subject>Republic of Korea - epidemiology</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sarcopenia</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Skeletal muscle</subject><subject>Smoking</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1v1DAQhiMEolXbP8ABWeLCJeDvxByQVlX5kCr1AmfLcSabtNl48djQ_nu8pJTCAV_G8jzzembeqnrB6BtGRfsWJVOmrSkztdIN5bV-Uh1zKlXNBedPH92PqjPEa1qO4kYy87w6EqxtuWH0uMINYvCTS1NYSAfpB8BC8AZmSG4mu4x-BuJSgiWvjFt6snWYYgAM-9FtoXARhjnfkn5CcAjvyIaM5TmNxI_gb-q8Jz6MISaCKfd3p9Wzwc0IZ_fxpPr64eLL-af68urj5_PNZe1lI1NtaEsp5waEUp4bMTRG0lY0HVXSeck70B2XQnOpPe2GpteONk0jme81qIGKk-r9qrvP3Q56D0uKbrb7OO1cvLPBTfbvzDKNdhu-W22ElMoUgdf3AjF8y4DJ7ib0MM9ugZDRciEYl4ZqVdBX_6DXIceljHegqCkOtYeO-Er5GBDL1h6aYdQebLWrrbbYan_ZanUpevl4jIeS3yYWQKwAltSyhfjn7__I_gSAGq7p</recordid><startdate>20191227</startdate><enddate>20191227</enddate><creator>Kim, Young Min</creator><creator>Kim, Jie-Hyun</creator><creator>Baik, Su Jung</creator><creator>Jung, Da Hyun</creator><creator>Park, Jae Jun</creator><creator>Youn, Young Hoon</creator><creator>Park, Hyojin</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3790-7701</orcidid><orcidid>https://orcid.org/0000-0002-9198-3326</orcidid></search><sort><creationdate>20191227</creationdate><title>Association between skeletal muscle attenuation and gastroesophageal reflux disease: A health check-up cohort study</title><author>Kim, Young Min ; Kim, Jie-Hyun ; Baik, Su Jung ; Jung, Da Hyun ; Park, Jae Jun ; Youn, Young Hoon ; Park, Hyojin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-90800229e355c293f7940837b054ac42be6b2436246c0bf7d6a077741cd6e5f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>692/4020/1503/2753/196</topic><topic>692/4020/2741/1479</topic><topic>Adult</topic><topic>Anthropometry</topic><topic>Barrett's esophagus</topic><topic>Biomarkers</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Disease Susceptibility</topic><topic>Electronic medical records</topic><topic>Endoscopy</topic><topic>Esophagitis</topic><topic>Female</topic><topic>Food consumption</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - epidemiology</topic><topic>Gastroesophageal Reflux - etiology</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Musculoskeletal system</topic><topic>Obesity</topic><topic>Patients</topic><topic>Republic of Korea - epidemiology</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sarcopenia</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Skeletal muscle</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Young Min</creatorcontrib><creatorcontrib>Kim, Jie-Hyun</creatorcontrib><creatorcontrib>Baik, Su Jung</creatorcontrib><creatorcontrib>Jung, Da Hyun</creatorcontrib><creatorcontrib>Park, Jae Jun</creatorcontrib><creatorcontrib>Youn, Young Hoon</creatorcontrib><creatorcontrib>Park, Hyojin</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Young Min</au><au>Kim, Jie-Hyun</au><au>Baik, Su Jung</au><au>Jung, Da Hyun</au><au>Park, Jae Jun</au><au>Youn, Young Hoon</au><au>Park, Hyojin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between skeletal muscle attenuation and gastroesophageal reflux disease: A health check-up cohort study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-12-27</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>20102</spage><epage>8</epage><pages>20102-8</pages><artnum>20102</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Sarcopenia is defined as skeletal muscle attenuation and has an association with metabolic syndrome. Metabolic syndrome, which includes obesity, is one of known predictive factors for gastroesophageal reflux disease (GERD). This study aimed to elucidate the association between sarcopenia and GERD. We retrospectively reviewed electronic medical records of 8,218 patients who were performed an upper gastrointestinal endoscopy at check-up center of the Gangnam Severance Hospital. GERD was diagnosed by endoscopic findings. Erosive reflux disease (ERD) included Barrett's esophagus and reflux esophagitis, with the exception of minimal change esophagitis. Sarcopenia was defined by appendicular skeletal muscle (skeletal muscle in the upper and lower limbs). Sarcopenic obesity was defined as the presence of both sarcopenia and obesity. Associations between sarcopenia and GERD, as well as between sarcopenic obesity and ERD, were analyzed. A total of 3,414 patients were diagnosed with GERD, and 574 (16.8%) had sarcopenia. Sarcopenia was independent predictive factor for GERD (odds ratio [OR] = 1.170, 95% confidence interval [CI]: 1.016–1.346,
P
= 0.029). In addition, male sex, smoking, alcohol, and diet, including sweets and fatty food, had a significant association with GERD. A total of 1,423 (17.3%) of 8,218 patients were diagnosed with ERD, and 302 (21.2%) had sarcopenia. Male sex, smoking, and fatty food consumption had a significant association with ERD. Moreover, sarcopenia (OR = 1.215, 95% CI: 1.019–1.449,
P
= 0.030), obesity (OR = 1.343, 95% CI: 1.163–1.552,
P
< 0.001), and sarcopenic obesity (OR = 1.406, 95% CI: 1.195–1.654,
P
< 0.001) were independent predictive factors for ERD. Sarcopenia is associated with GERD, and sarcopenic obesity may be predictive factor for ERD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31882910</pmid><doi>10.1038/s41598-019-56702-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3790-7701</orcidid><orcidid>https://orcid.org/0000-0002-9198-3326</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 692/4020/1503/2753/196 692/4020/2741/1479 Adult Anthropometry Barrett's esophagus Biomarkers Cohort analysis Cohort Studies Cross-Sectional Studies Disease Susceptibility Electronic medical records Endoscopy Esophagitis Female Food consumption Gastroesophageal reflux Gastroesophageal Reflux - epidemiology Gastroesophageal Reflux - etiology Gastroesophageal Reflux - physiopathology Humanities and Social Sciences Humans Male Metabolic disorders Metabolic syndrome Middle Aged multidisciplinary Muscle, Skeletal - physiopathology Musculoskeletal system Obesity Patients Republic of Korea - epidemiology Retrospective Studies Risk Assessment Risk Factors Sarcopenia Science Science (multidisciplinary) Skeletal muscle Smoking |
| title | Association between skeletal muscle attenuation and gastroesophageal reflux disease: A health check-up cohort study |
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