Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H

Currently, an effective targeted therapy for pancreatitis is lacking. Hereditary pancreatitis (HP) is a heritable, autosomal-dominant disorder with recurrent acute pancreatitis (AP) progressing to chronic pancreatitis (CP) and a markedly increased risk of pancreatic cancer. In 1996, mutations in PRS...

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Veröffentlicht in:	The Journal of clinical investigation 2020-01, Vol.130 (1), p.189-202
Hauptverfasser:	Gui, Fu, Zhang, Yuebo, Wan, Jianhua, Zhan, Xianbao, Yao, Yao, Li, Yinghua, Haddock, Ashley N, Shi, Ji, Guo, Jia, Chen, Jiaxiang, Zhu, Xiaohui, Edenfield, Brandy H, Zhuang, Lu, Hu, Cheng, Wang, Ying, Mukhopadhyay, Debabrata, Radisky, Evette S, Zhang, Lizhi, Lugea, Aurelia, Pandol, Stephen J, Bi, Yan, Ji, Baoan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Apoptosis Artificial chromosomes Biomedical research Deoxyribonucleic acid DNA DNA damage Edema Gene expression Hereditary diseases Inflammation Mortality Mutation Pancreatic cancer Pancreatitis Pathogenesis Proteins Transgenic animals Trypsin
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