Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer's disease mouse model

The implication of epigenetic mechanisms in Alzheimer's disease (AD) has been demonstrated in several studies. UNC0642, a specific and potent inhibitor of methyltransferase activity G9a/GLP (G9a-like) complex, was evaluated in the 5XFAD mouse model. UNC0642 treatment rescued 5XFAD cognition imp...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2019-12, Vol.11 (23), p.11591-11608
Hauptverfasser:	Griñán-Ferré, Christian, Marsal-García, Laura, Bellver-Sanchis, Aina, Kondengaden, Shukkoor Muhammed, Turga, Ravi Chakra, Vázquez, Santiago, Pallàs, Mercè
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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