Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats
Background Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial cells rather than neurons, and only a few of them survive after transplantation due to the inflammatory environment. Methods In this study...
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| Veröffentlicht in: | CNS neuroscience & therapeutics 2020-01, Vol.26 (1), p.55-65 |
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| creator | Qian, Yuan Chen, Xiao‐Xiang Wang, Wei Li, Jun‐Jun Wang, Xian‐Peng Tang, Zhi‐Wei Xu, Jiao‐Tian Lin, Hai Yang, Zhi‐Yong Li, Li‐Yan Song, Xiao‐Bin Guo, Jia‐Zhi Bian, Li‐Gong Zhou, Lei Lu, Di Deng, Xing‐Li |
| description | Background
Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial cells rather than neurons, and only a few of them survive after transplantation due to the inflammatory environment.
Methods
In this study, neural stem cells (NSCs) and microglial cells both forced with the Nurr1 gene were transplanted into the striatum of the rat model of PD. The results were evaluated through reverse transcription polymerase chain reaction (RT‐PCR), Western blot, and immunofluorescence analysis.
Results
The behavioral abnormalities of PD rats were improved by combined transplantation of NSCs and microglia, both forced with Nurr1. The number of tyrosine hydroxylase+ cells in the striatum of PD rats increased, and the number of Iba1+ cells decreased compared with the other groups. Moreover, the dopamine neurons differentiated from grafted NSCs could still be detected in the striatum of PD rats after 5 months.
Conclusions
The results suggested that transplantation of Nurr1‐overexpressing NSCs and microglia could improve the inhospitable host brain environments, which will be a new potential strategy for the cell replacement therapy in PD. |
| doi_str_mv | 10.1111/cns.13149 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6930818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2232004340</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4439-d5938df265e49776c6b32229ee86f6f7eec32aae1823c3cfab4168e98963e6283</originalsourceid><addsrcrecordid>eNp1kctOGzEUhq0KVCh00RdAltiURcC3eOwNUhWVi4ToAlhbjnMmmM7YU3smLbs-Qp-RJ8EhEFEkvLElf_r0n_Mj9IWSQ1rOkQv5kHIq9Ae0TavxeDTWQm-s35xsoU853xEimdLqI9rilKhKCL2Nbq-TDblrbOht72PAscaXQ0r04e-_uIAEf7oEOfswxwGGZBuce2ixg6bJ2IYZbr1Lcd54i-uYcJ-gaArc2fTThxyDtwEn2-ddtFnbJsPn53sH3Zx8v56cjS5-nJ5Pvl2MnBBcj2YlrprVTI5B6KqSTk45Y0wDKFnLugJwnFkLVDHuuKvtVFCpQCstOZTx-A46Xnm7YdrCzEHoS2rTJd_adG-i9eb_n-BvzTwujCx7UnQp-PosSPHXALk3rc_LeW2AOGTDGGeECC5IQfffoHdxSKGMZxgXkivF1ZI6WFFlUTknqNdhKDHL_kzpzzz1V9i91-nX5EthBThaAb99A_fvm8zk8mqlfASzVKgP</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2346388380</pqid></control><display><type>article</type><title>Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats</title><source>Wiley Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><creator>Qian, Yuan ; Chen, Xiao‐Xiang ; Wang, Wei ; Li, Jun‐Jun ; Wang, Xian‐Peng ; Tang, Zhi‐Wei ; Xu, Jiao‐Tian ; Lin, Hai ; Yang, Zhi‐Yong ; Li, Li‐Yan ; Song, Xiao‐Bin ; Guo, Jia‐Zhi ; Bian, Li‐Gong ; Zhou, Lei ; Lu, Di ; Deng, Xing‐Li</creator><creatorcontrib>Qian, Yuan ; Chen, Xiao‐Xiang ; Wang, Wei ; Li, Jun‐Jun ; Wang, Xian‐Peng ; Tang, Zhi‐Wei ; Xu, Jiao‐Tian ; Lin, Hai ; Yang, Zhi‐Yong ; Li, Li‐Yan ; Song, Xiao‐Bin ; Guo, Jia‐Zhi ; Bian, Li‐Gong ; Zhou, Lei ; Lu, Di ; Deng, Xing‐Li</creatorcontrib><description>Background
Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial cells rather than neurons, and only a few of them survive after transplantation due to the inflammatory environment.
Methods
In this study, neural stem cells (NSCs) and microglial cells both forced with the Nurr1 gene were transplanted into the striatum of the rat model of PD. The results were evaluated through reverse transcription polymerase chain reaction (RT‐PCR), Western blot, and immunofluorescence analysis.
Results
The behavioral abnormalities of PD rats were improved by combined transplantation of NSCs and microglia, both forced with Nurr1. The number of tyrosine hydroxylase+ cells in the striatum of PD rats increased, and the number of Iba1+ cells decreased compared with the other groups. Moreover, the dopamine neurons differentiated from grafted NSCs could still be detected in the striatum of PD rats after 5 months.
Conclusions
The results suggested that transplantation of Nurr1‐overexpressing NSCs and microglia could improve the inhospitable host brain environments, which will be a new potential strategy for the cell replacement therapy in PD.</description><identifier>ISSN: 1755-5930</identifier><identifier>EISSN: 1755-5949</identifier><identifier>DOI: 10.1111/cns.13149</identifier><identifier>PMID: 31087449</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Basal ganglia ; Cell differentiation ; Central nervous system diseases ; Dopamine ; Glial cells ; Growth factors ; Hydroxylase ; Immunofluorescence ; Inflammation ; inflammatory ; Laboratory animals ; Microglia ; Microglial cells ; Movement disorders ; Neostriatum ; Neural stem cells ; Neurodegenerative diseases ; Neuronal-glial interactions ; Neurons ; Nuclear receptors ; nuclear receptor‐related factor 1 ; Nurr1 protein ; Original ; Parkinson's disease ; Polymerase chain reaction ; Proteins ; Reverse transcription ; Stem cell transplantation ; Stem cells ; Surgery ; Tyrosine 3-monooxygenase</subject><ispartof>CNS neuroscience & therapeutics, 2020-01, Vol.26 (1), p.55-65</ispartof><rights>2019 The Authors. Published by John Wiley & Sons Ltd.</rights><rights>2019 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4439-d5938df265e49776c6b32229ee86f6f7eec32aae1823c3cfab4168e98963e6283</citedby><cites>FETCH-LOGICAL-c4439-d5938df265e49776c6b32229ee86f6f7eec32aae1823c3cfab4168e98963e6283</cites><orcidid>0000-0001-5716-8451</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930818/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930818/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31087449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qian, Yuan</creatorcontrib><creatorcontrib>Chen, Xiao‐Xiang</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Li, Jun‐Jun</creatorcontrib><creatorcontrib>Wang, Xian‐Peng</creatorcontrib><creatorcontrib>Tang, Zhi‐Wei</creatorcontrib><creatorcontrib>Xu, Jiao‐Tian</creatorcontrib><creatorcontrib>Lin, Hai</creatorcontrib><creatorcontrib>Yang, Zhi‐Yong</creatorcontrib><creatorcontrib>Li, Li‐Yan</creatorcontrib><creatorcontrib>Song, Xiao‐Bin</creatorcontrib><creatorcontrib>Guo, Jia‐Zhi</creatorcontrib><creatorcontrib>Bian, Li‐Gong</creatorcontrib><creatorcontrib>Zhou, Lei</creatorcontrib><creatorcontrib>Lu, Di</creatorcontrib><creatorcontrib>Deng, Xing‐Li</creatorcontrib><title>Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats</title><title>CNS neuroscience & therapeutics</title><addtitle>CNS Neurosci Ther</addtitle><description>Background
Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial cells rather than neurons, and only a few of them survive after transplantation due to the inflammatory environment.
Methods
In this study, neural stem cells (NSCs) and microglial cells both forced with the Nurr1 gene were transplanted into the striatum of the rat model of PD. The results were evaluated through reverse transcription polymerase chain reaction (RT‐PCR), Western blot, and immunofluorescence analysis.
Results
The behavioral abnormalities of PD rats were improved by combined transplantation of NSCs and microglia, both forced with Nurr1. The number of tyrosine hydroxylase+ cells in the striatum of PD rats increased, and the number of Iba1+ cells decreased compared with the other groups. Moreover, the dopamine neurons differentiated from grafted NSCs could still be detected in the striatum of PD rats after 5 months.
Conclusions
The results suggested that transplantation of Nurr1‐overexpressing NSCs and microglia could improve the inhospitable host brain environments, which will be a new potential strategy for the cell replacement therapy in PD.</description><subject>Basal ganglia</subject><subject>Cell differentiation</subject><subject>Central nervous system diseases</subject><subject>Dopamine</subject><subject>Glial cells</subject><subject>Growth factors</subject><subject>Hydroxylase</subject><subject>Immunofluorescence</subject><subject>Inflammation</subject><subject>inflammatory</subject><subject>Laboratory animals</subject><subject>Microglia</subject><subject>Microglial cells</subject><subject>Movement disorders</subject><subject>Neostriatum</subject><subject>Neural stem cells</subject><subject>Neurodegenerative diseases</subject><subject>Neuronal-glial interactions</subject><subject>Neurons</subject><subject>Nuclear receptors</subject><subject>nuclear receptor‐related factor 1</subject><subject>Nurr1 protein</subject><subject>Original</subject><subject>Parkinson's disease</subject><subject>Polymerase chain reaction</subject><subject>Proteins</subject><subject>Reverse transcription</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Surgery</subject><subject>Tyrosine 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Yuan</creator><creator>Chen, Xiao‐Xiang</creator><creator>Wang, Wei</creator><creator>Li, Jun‐Jun</creator><creator>Wang, Xian‐Peng</creator><creator>Tang, Zhi‐Wei</creator><creator>Xu, Jiao‐Tian</creator><creator>Lin, Hai</creator><creator>Yang, Zhi‐Yong</creator><creator>Li, Li‐Yan</creator><creator>Song, Xiao‐Bin</creator><creator>Guo, Jia‐Zhi</creator><creator>Bian, Li‐Gong</creator><creator>Zhou, Lei</creator><creator>Lu, Di</creator><creator>Deng, Xing‐Li</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5716-8451</orcidid></search><sort><creationdate>202001</creationdate><title>Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats</title><author>Qian, Yuan ; Chen, Xiao‐Xiang ; Wang, Wei ; Li, Jun‐Jun ; Wang, Xian‐Peng ; Tang, Zhi‐Wei ; Xu, Jiao‐Tian ; Lin, Hai ; Yang, Zhi‐Yong ; Li, Li‐Yan ; Song, Xiao‐Bin ; Guo, Jia‐Zhi ; Bian, Li‐Gong ; Zhou, Lei ; Lu, Di ; Deng, Xing‐Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4439-d5938df265e49776c6b32229ee86f6f7eec32aae1823c3cfab4168e98963e6283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Basal ganglia</topic><topic>Cell differentiation</topic><topic>Central nervous system diseases</topic><topic>Dopamine</topic><topic>Glial cells</topic><topic>Growth factors</topic><topic>Hydroxylase</topic><topic>Immunofluorescence</topic><topic>Inflammation</topic><topic>inflammatory</topic><topic>Laboratory animals</topic><topic>Microglia</topic><topic>Microglial cells</topic><topic>Movement disorders</topic><topic>Neostriatum</topic><topic>Neural stem cells</topic><topic>Neurodegenerative diseases</topic><topic>Neuronal-glial interactions</topic><topic>Neurons</topic><topic>Nuclear receptors</topic><topic>nuclear receptor‐related factor 1</topic><topic>Nurr1 protein</topic><topic>Original</topic><topic>Parkinson's disease</topic><topic>Polymerase chain reaction</topic><topic>Proteins</topic><topic>Reverse transcription</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Surgery</topic><topic>Tyrosine 3-monooxygenase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qian, Yuan</creatorcontrib><creatorcontrib>Chen, Xiao‐Xiang</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Li, Jun‐Jun</creatorcontrib><creatorcontrib>Wang, Xian‐Peng</creatorcontrib><creatorcontrib>Tang, Zhi‐Wei</creatorcontrib><creatorcontrib>Xu, Jiao‐Tian</creatorcontrib><creatorcontrib>Lin, Hai</creatorcontrib><creatorcontrib>Yang, Zhi‐Yong</creatorcontrib><creatorcontrib>Li, 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for treating parkinsonian rats</atitle><jtitle>CNS neuroscience & therapeutics</jtitle><addtitle>CNS Neurosci Ther</addtitle><date>2020-01</date><risdate>2020</risdate><volume>26</volume><issue>1</issue><spage>55</spage><epage>65</epage><pages>55-65</pages><issn>1755-5930</issn><eissn>1755-5949</eissn><abstract>Background
Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial cells rather than neurons, and only a few of them survive after transplantation due to the inflammatory environment.
Methods
In this study, neural stem cells (NSCs) and microglial cells both forced with the Nurr1 gene were transplanted into the striatum of the rat model of PD. The results were evaluated through reverse transcription polymerase chain reaction (RT‐PCR), Western blot, and immunofluorescence analysis.
Results
The behavioral abnormalities of PD rats were improved by combined transplantation of NSCs and microglia, both forced with Nurr1. The number of tyrosine hydroxylase+ cells in the striatum of PD rats increased, and the number of Iba1+ cells decreased compared with the other groups. Moreover, the dopamine neurons differentiated from grafted NSCs could still be detected in the striatum of PD rats after 5 months.
Conclusions
The results suggested that transplantation of Nurr1‐overexpressing NSCs and microglia could improve the inhospitable host brain environments, which will be a new potential strategy for the cell replacement therapy in PD.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>31087449</pmid><doi>10.1111/cns.13149</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5716-8451</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library Open Access; PubMed Central |
| subjects | Basal ganglia Cell differentiation Central nervous system diseases Dopamine Glial cells Growth factors Hydroxylase Immunofluorescence Inflammation inflammatory Laboratory animals Microglia Microglial cells Movement disorders Neostriatum Neural stem cells Neurodegenerative diseases Neuronal-glial interactions Neurons Nuclear receptors nuclear receptor‐related factor 1 Nurr1 protein Original Parkinson's disease Polymerase chain reaction Proteins Reverse transcription Stem cell transplantation Stem cells Surgery Tyrosine 3-monooxygenase |
| title | Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
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