Cryptotanshinone Inhibites Bladder Cancer Cell Proliferation and Promotes Apoptosis via the PTEN/PI3K/AKT Pathway
Cryptotanshinone (CTT), extracted from the root of (Danshen), exhibits activities against a variety of human cancers and . The purpose of this study was to investigate the potential inhibitory effect of CTT on bladder cancer. In this study, we found that CTT inhibited bladder cancer cell proliferati...
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| Veröffentlicht in: | Journal of Cancer 2020, Vol.11 (2), p.488-499 |
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| container_title | Journal of Cancer |
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| creator | Liu, Yadong Lin, Fanlu Chen, Yaodong Wang, Rui Liu, Jiannan Jin, Yinshan An, Ruihua |
| description | Cryptotanshinone (CTT), extracted from the root of
(Danshen), exhibits activities against a variety of human cancers
and
. The purpose of this study was to investigate the potential inhibitory effect of CTT on bladder cancer. In this study, we found that CTT inhibited bladder cancer cell proliferation, migration, and invasion and promoted apoptosis. In addition, CTT modulated the expression of proteins via the PI3K/AKT pathway, and the inhibition of PI3K/AKT signalling was due to induction of PTEN expression. Taken together, the results of the present study demonstrated the anticancer effect of CTT on bladder cancer cells, which might be associated with the downregulation of PI3K/AKT/mTOR and NF-κB signalling pathway proteins, and this inhibition was mediated by the induction of PTEN. |
| doi_str_mv | 10.7150/jca.31422 |
| format | Article |
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(Danshen), exhibits activities against a variety of human cancers
and
. The purpose of this study was to investigate the potential inhibitory effect of CTT on bladder cancer. In this study, we found that CTT inhibited bladder cancer cell proliferation, migration, and invasion and promoted apoptosis. In addition, CTT modulated the expression of proteins via the PI3K/AKT pathway, and the inhibition of PI3K/AKT signalling was due to induction of PTEN expression. Taken together, the results of the present study demonstrated the anticancer effect of CTT on bladder cancer cells, which might be associated with the downregulation of PI3K/AKT/mTOR and NF-κB signalling pathway proteins, and this inhibition was mediated by the induction of PTEN.</description><identifier>ISSN: 1837-9664</identifier><identifier>EISSN: 1837-9664</identifier><identifier>DOI: 10.7150/jca.31422</identifier><identifier>PMID: 31897244</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher Pty Ltd</publisher><subject>Antibodies ; Apoptosis ; Bladder cancer ; Cell culture ; Cell growth ; Fluorides ; Kinases ; Medical prognosis ; Phosphatase ; Research Paper</subject><ispartof>Journal of Cancer, 2020, Vol.11 (2), p.488-499</ispartof><rights>The author(s).</rights><rights>2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-4f730405582f3acbc4c0927bbf70790c354fa736032a46f5140c8ba6d09754a03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930428/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930428/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31897244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yadong</creatorcontrib><creatorcontrib>Lin, Fanlu</creatorcontrib><creatorcontrib>Chen, Yaodong</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Liu, Jiannan</creatorcontrib><creatorcontrib>Jin, Yinshan</creatorcontrib><creatorcontrib>An, Ruihua</creatorcontrib><title>Cryptotanshinone Inhibites Bladder Cancer Cell Proliferation and Promotes Apoptosis via the PTEN/PI3K/AKT Pathway</title><title>Journal of Cancer</title><addtitle>J Cancer</addtitle><description>Cryptotanshinone (CTT), extracted from the root of
(Danshen), exhibits activities against a variety of human cancers
and
. The purpose of this study was to investigate the potential inhibitory effect of CTT on bladder cancer. In this study, we found that CTT inhibited bladder cancer cell proliferation, migration, and invasion and promoted apoptosis. In addition, CTT modulated the expression of proteins via the PI3K/AKT pathway, and the inhibition of PI3K/AKT signalling was due to induction of PTEN expression. Taken together, the results of the present study demonstrated the anticancer effect of CTT on bladder cancer cells, which might be associated with the downregulation of PI3K/AKT/mTOR and NF-κB signalling pathway proteins, and this inhibition was mediated by the induction of PTEN.</description><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Bladder cancer</subject><subject>Cell culture</subject><subject>Cell growth</subject><subject>Fluorides</subject><subject>Kinases</subject><subject>Medical prognosis</subject><subject>Phosphatase</subject><subject>Research Paper</subject><issn>1837-9664</issn><issn>1837-9664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU9PGzEQxa0KVBDl0C9QWeJCDyH-t-vdC1KIgEagNof0bM16vV1HGzvYDlW-PV6giOLLWJ6f3jzPQ-grJReSFmS61nDBqWDsEzqmFZeTuizFwbv7ETqNcU3y4TWTgn9GR5xWtWRCHKOHedhvk0_gYm-ddwYvXG8bm0zEVwO0rQl4Dk6PxQwDXgY_2M4ESNY7DK4dXzZ-xGdbn5WijfjRAk69wcvV9c_pcsHvprO7FV5C6v_C_gs67GCI5vS1nqDfN9er-Y_J_a_bxXx2P9GC8DQRneREkKKoWMdBN1poku03TSeJrInmhehA8pJwBqLsCiqIrhooW1LLQgDhJ-jyRXe7azam1calAIPaBruBsFcerPq_42yv_vhHVdZ5MKuywPmrQPAPOxOT2tio8xLAGb-LinGex9OK0oyefUDXfhdc_p5iRZ2DYEU5Cn5_oXTwMQbTvZmhRI1Zqpyles4ys9_eu38j_yXHnwAZppk-</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Liu, Yadong</creator><creator>Lin, Fanlu</creator><creator>Chen, Yaodong</creator><creator>Wang, Rui</creator><creator>Liu, Jiannan</creator><creator>Jin, Yinshan</creator><creator>An, Ruihua</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2020</creationdate><title>Cryptotanshinone Inhibites Bladder Cancer Cell Proliferation and Promotes Apoptosis via the PTEN/PI3K/AKT Pathway</title><author>Liu, Yadong ; Lin, Fanlu ; Chen, Yaodong ; Wang, Rui ; Liu, Jiannan ; Jin, Yinshan ; An, Ruihua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-4f730405582f3acbc4c0927bbf70790c354fa736032a46f5140c8ba6d09754a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibodies</topic><topic>Apoptosis</topic><topic>Bladder cancer</topic><topic>Cell culture</topic><topic>Cell growth</topic><topic>Fluorides</topic><topic>Kinases</topic><topic>Medical prognosis</topic><topic>Phosphatase</topic><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yadong</creatorcontrib><creatorcontrib>Lin, Fanlu</creatorcontrib><creatorcontrib>Chen, Yaodong</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Liu, Jiannan</creatorcontrib><creatorcontrib>Jin, Yinshan</creatorcontrib><creatorcontrib>An, Ruihua</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yadong</au><au>Lin, Fanlu</au><au>Chen, Yaodong</au><au>Wang, Rui</au><au>Liu, Jiannan</au><au>Jin, Yinshan</au><au>An, Ruihua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cryptotanshinone Inhibites Bladder Cancer Cell Proliferation and Promotes Apoptosis via the PTEN/PI3K/AKT Pathway</atitle><jtitle>Journal of Cancer</jtitle><addtitle>J Cancer</addtitle><date>2020</date><risdate>2020</risdate><volume>11</volume><issue>2</issue><spage>488</spage><epage>499</epage><pages>488-499</pages><issn>1837-9664</issn><eissn>1837-9664</eissn><abstract>Cryptotanshinone (CTT), extracted from the root of
(Danshen), exhibits activities against a variety of human cancers
and
. The purpose of this study was to investigate the potential inhibitory effect of CTT on bladder cancer. In this study, we found that CTT inhibited bladder cancer cell proliferation, migration, and invasion and promoted apoptosis. In addition, CTT modulated the expression of proteins via the PI3K/AKT pathway, and the inhibition of PI3K/AKT signalling was due to induction of PTEN expression. Taken together, the results of the present study demonstrated the anticancer effect of CTT on bladder cancer cells, which might be associated with the downregulation of PI3K/AKT/mTOR and NF-κB signalling pathway proteins, and this inhibition was mediated by the induction of PTEN.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher Pty Ltd</pub><pmid>31897244</pmid><doi>10.7150/jca.31422</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Apoptosis Bladder cancer Cell culture Cell growth Fluorides Kinases Medical prognosis Phosphatase Research Paper |
| title | Cryptotanshinone Inhibites Bladder Cancer Cell Proliferation and Promotes Apoptosis via the PTEN/PI3K/AKT Pathway |
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